DSpace at EWHA: Synthesis of new β-lactam analogs and evaluation of their histone deacetylase (HDAC) activity

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DC Field	Value	Language
dc.contributor.author	오세관	*
dc.date.accessioned	2018-06-02T08:13:57Z	-
dc.date.available	2018-06-02T08:13:57Z	-
dc.date.issued	2007	*
dc.identifier.issn	0932-0776	*
dc.identifier.other	OAK-17856	*
dc.identifier.uri	https://dspace.ewha.ac.kr/handle/2015.oak/243940	-
dc.description.abstract	A simple synthesis of the β-lactams 11-13 and 16-17 as novel histone deacetylase (HDAC) inhibitors is described. The key synthetic strategies involved the O-alkylation of 6-APA and the coupling reactions of freshly prepared N-carbobenzyloxy-L-prolines 5 and 6 and 6-aminopenicillanates 8-10 and 15 in high yields. It was found that all compounds show potent growth inhibitory activity on human tumor cell lines, the most potent compound 16 exhibiting an IC50 = 2.1 μM in vitro. © 2007 Verlag der Zeitschrift für Naturforschung.	*
dc.language	English	*
dc.title	Synthesis of new β-lactam analogs and evaluation of their histone deacetylase (HDAC) activity	*
dc.type	Article	*
dc.relation.issue	11	*
dc.relation.volume	62	*
dc.relation.index	SCI	*
dc.relation.index	SCIE	*
dc.relation.index	SCOPUS	*
dc.relation.startpage	1459	*
dc.relation.lastpage	1464	*
dc.relation.journaltitle	Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences	*
dc.identifier.scopusid	2-s2.0-35948933463	*
dc.author.google	Oh S.	*
dc.author.google	Jung J.-C.	*
dc.contributor.scopusid	오세관(7404103757)	*
dc.date.modifydate	20240118133340	*