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Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal
- Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal
- Nguyen Thuy Chinh; Nguyen Thi Thu Trang; Tran Thi Mai; Dinh Thi Mai Thanh; Tran Huu Trung; Trinh Hoang Trung; Le Van Quan; Nguyen Thi Hoa; Can Van Mao; Nguyen Trong Nghia; Nguyen Thanh Hai; Tran Hong Anh; Tran Viet Hung; Choy, Jin-Ho; Nguyen Van Loi; Rajesh, Baskaran; Thai Hoang
- Ewha Authors
- Issue Date
- Journal Title
- JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
- 1533-4880; 1533-4899
- vol. 18, no. 4, pp. 2294 - 2303
- PLA/CS/Nifedipine Nanoparticles; In Vivo Test; Zeta Potential; Water Contact Angle; Blood Pressure; Heart Rate
- AMER SCIENTIFIC PUBLISHERS
- SCIE; SCOPUS
- This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the in vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The in vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately.
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