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Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal

Title
Polylactic Acid/Chitosan Nanoparticles Loading Nifedipine: Characterization Findings and In Vivo Investigation in Animal
Authors
Nguyen Thuy ChinhNguyen Thi Thu TrangTran Thi MaiDinh Thi Mai ThanhTran Huu TrungTrinh Hoang TrungLe Van QuanNguyen Thi HoaCan Van MaoNguyen Trong NghiaNguyen Thanh HaiTran Hong AnhTran Viet HungChoy, Jin-HoNguyen Van LoiRajesh, BaskaranThai Hoang
Ewha Authors
최진호
Issue Date
2018
Journal Title
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN
1533-4880JCR Link1533-4899JCR Link
Citation
vol. 18, no. 4, pp. 2294 - 2303
Keywords
PLA/CS/Nifedipine NanoparticlesIn Vivo TestZeta PotentialWater Contact AngleBlood PressureHeart Rate
Publisher
AMER SCIENTIFIC PUBLISHERS
Indexed
SCIE; SCOPUS WOS
Abstract
This paper presents the results of zeta potential, water contact angle, atomic force microscopy image, in vitro solubility, and content of heavy metals in polylactic acid (PLA)/chitosan (CS) nanoparticles loading nifedipine. In addition, the in vivo test of the PLA/CS nanoparticles loading nifedipine in the mice is also one of highlights of this work. The Zeta potential result shows that the charged surface of the PLA/CS nanoparticles loading nifedipine is neutral, negative or complex depending on nifedipine content. Nifedipine plays a role in increase of hydrophobic property, swelling degree and regular surface as well as decrease of surface rough of the nanoparticles. The PLA/CS/nifedipine nanoparticles are dissolved in the solutions with pH 6.8, pH 4.5 and pH 1.2. The in vivo test of PLA/CS nanoparticles loading nifedipine on mice was evaluated by the change in diastolic pressure, systolic pressure, arterial pressure and heart rate. The obtained results confirm that the PLA/CS nanoparticles loading nifedipine is suitable to apply in the treatment of hypertension patients lately.
DOI
10.1166/jnn.2018.14537
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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