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99mTc-labeled 1-thio-β-d-glucose as a new tumor-seeking agent: Synthesis and tumor cell uptake assay

Title
99mTc-labeled 1-thio-β-d-glucose as a new tumor-seeking agent: Synthesis and tumor cell uptake assay
Authors
Jun Oh S.Ryu J.-S.Yoon E.-J.Sun Bae M.Joo Choi S.Bae Park K.Hyuk Moon D.
Ewha Authors
배문선
Issue Date
2006
Journal Title
Applied Radiation and Isotopes
ISSN
0969-8043JCR Link
Citation
Applied Radiation and Isotopes vol. 64, no. 2, pp. 207 - 215
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
99mTc-labeled 1-thio-β-d-glucose (99mTc-1-TG) was synthesized under different ligand concentrations. 1-Thio-β-d-glucose (1-TG) showed different chemical properties and higher stability at acid pH as compared to neutral and basic pH. Under different ligand concentrations, 99mTc-1-TG was obtained with high labeling efficiency of >97%, but the HPLC chromatogram varied with the ligand concentration. The results of a tumor cell uptake assay also depended on the ligand concentration. With the lowest ligand concentration tested (0.5 mg/ml of 1-TG), we obtained the highest uptake. With different glucose and insulin concentrations, 99mTc-1-TG uptake was not significantly different from that of [18F]FDG. © 2005 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.apradiso.2005.07.022
Appears in Collections:
의과대학 > 의학과 > Journal papers
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