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Reactivities of mononuclear non-heme iron intermediates including evidence that iron(III) hydroperoxo species is a sluggish oxidant

Title
Reactivities of mononuclear non-heme iron intermediates including evidence that iron(III) hydroperoxo species is a sluggish oxidant
Authors
Park M.J.Lee J.Sun Y.Kim J.Nam W.
Ewha Authors
남원우김진흥
SCOPUS Author ID
남원우scopus; 김진흥scopus
Issue Date
2006
Journal Title
Journal of the American Chemical Society
ISSN
0002-7863JCR Link
Citation
Journal of the American Chemical Society vol. 128, no. 8, pp. 2630 - 2634
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
There is an intriguing, current controversy on the involvement of iron(III)-hydroperoxo species as a "second electrophilic oxidant" in oxygenation reactions by heme and non-heme iron enzymes and their model compounds. In the present work, we have performed reactivity studies of the iron-hydroperoxo species in nucleophilic and electrophilic reactions, with in situ-generated mononuclear non-heme iron(III)-hydroperoxo complexes that have been well characterized with various spectroscopic techniques. The intermediates did not show any reactivities in the nucleophilic (e.g., aldehyde deformylation) and electrophilic (e.g., oxidation of sulfide and olefin) reactions. These results demonstrate that non-heme iron(III)-hydroperoxo species are sluggish oxidants and that the oxidizing power of the intermediates cannot compete with that of high-valent iron(IV)-oxo complexes. We have also reported reactivities of mononuclear non-heme iron(III)-peroxo and iron(IV)-oxo complexes in the aldehyde deformylation and the oxidation of sulfides, respectively. © 2006 American Chemical Society.
DOI
10.1021/ja055709q
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자연과학대학 > 화학·나노과학전공 > Journal papers
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