Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2018-05-30T08:14:03Z | - |
dc.date.available | 2018-05-30T08:14:03Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0969-9961 | - |
dc.identifier.other | OAK-3267 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243490 | - |
dc.description.abstract | The β-secretase cleaved Aβ-bearing carboxy-terminal fragments (βCTFs) of amyloid precursor protein (APP) in neural cells have been suggested to be cytotoxic. However, the functional significance of βCTFs in vivo remains elusive. We created a transgenic mouse line Tg-βCTF99/B6 expressing the human βCTF99 in the brain of inbred C57BL/6 strain. Tg-βCTF99/B6 mouse brain at 12-16 months showed severely down-regulated calbindin, phospho-CREB, and Bcl-xL expression and up-regulated phospho-JNK, Bcl-2, and Bax expression. Neuronal cell density in the Tg-βCTF99/B6 cerebral cortex at 16-18 months was lower than that of the non-transgenic control, but not at 5 months. At 11-14 months, Tg-βCTF99/B6 mice displayed cognitive impairments and increased anxiety, which were not observed at 5 months. These results suggest that increased βCTF99 expression is highly detrimental to the aging brain and that it produces a progressive and age-dependent AD-like pathogenesis. © 2005 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Progressive neuronal loss and behavioral impairments of transgenic C57BL/6 inbred mice expressing the carboxy terminus of amyloid precursor protein | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 22 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 10 | - |
dc.relation.lastpage | 24 | - |
dc.relation.journaltitle | Neurobiology of Disease | - |
dc.identifier.doi | 10.1016/j.nbd.2005.09.011 | - |
dc.identifier.wosid | WOS:000236595200002 | - |
dc.identifier.scopusid | 2-s2.0-33645092125 | - |
dc.author.google | Lee K.-W. | - |
dc.author.google | Im J.-Y. | - |
dc.author.google | Song J.-S. | - |
dc.author.google | Lee S.H. | - |
dc.author.google | Lee H.-J. | - |
dc.author.google | Ha H.-Y. | - |
dc.author.google | Koh J.-Y. | - |
dc.author.google | Gwag B.J. | - |
dc.author.google | Yang S.-D. | - |
dc.author.google | Paik S.-G. | - |
dc.author.google | Han P.-L. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |