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Interaction between primary alveolar macrophages and primary alveolar type II cells under basal conditions and after lipopolysaccharide or quartz exposure
- Title
- Interaction between primary alveolar macrophages and primary alveolar type II cells under basal conditions and after lipopolysaccharide or quartz exposure
- Authors
- Kanj R.S.; Kang J.L.; Castranova V.
- Ewha Authors
- 이지희
- SCOPUS Author ID
- 이지희
- Issue Date
- 2006
- Journal Title
- Journal of Toxicology and Environmental Health - Part A: Current Issues
- ISSN
- 1528-7394
- Citation
- Journal of Toxicology and Environmental Health - Part A: Current Issues vol. 69, no. 11, pp. 1097 - 1116
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Intercellular communications between alveolar macrophages (AM) and alveolar epithelial type II (TII) cells have been suggested to be important in cellular responses. The main objective of this study was to improve our understanding of the interactions between AM and TII cells that might occur in the lung. In the present investigation, this interaction was studied under different interaction conditions (transwell or mixed coculture) and different exposure conditions (basal, lipopolysaccharide [LPS] exposure, or silica exposure). Studies also attempted different approaches to identify specific mediator(s) involved in this interaction. The following findings were made: (1) Surfactant released from TII cells appears to exert an inhibitory effect on AM activity. (2) Basal transwell coculture conditions are better than mixed coculture conditions to study AM/TII cell interactions, since the inhibitory effect of the surfactant in the transwell coculture is minimized. (3) AM/TII cell interaction is dependent on cell culture (transwell vs mixed) and exposure conditions. (4) Oxidants, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, prostaglandins, and leukotrienes probably do not independently affect the AM/TII intercellular interaction; instead, they appear to indirectly modulate the complex pathways of AM/TII communication. Copyright© Taylor & Francis Group, LLC.
- DOI
- 10.1080/14736480500360504
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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