Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2018-05-30T08:13:56Z | - |
dc.date.available | 2018-05-30T08:13:56Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-3360 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243445 | - |
dc.description.abstract | The roles of JSAP1 and JIP1 in cell adhesion and spreading were examined using mouse embryonic fibroblasts (MEFs) deficient in JIP1 (JIP1-KO), JSAP1 (JSAP1-KO), and in both JIP1 and JSAP1 (double-KO), and by using their wild type. After being plated on fibronectin-coated culture plates, wild type MEFs rapidly adhered and differentiated to typical longitudinal fibroblasts in 4 h. JSAP1-KO MEFs showed a similar sequence of adhesion and cell spreading, but their adhesion was weak, and cell spreading sequence proceeded in a delayed manner compared with the wild type. In spreading JSAP1-KO MEFs, adhesion-triggered actin cytoskeleton reorganization and FAK activation proceeded at a slower pace than in wild type MEFs. The cellular properties of double-KO MEFs and JIP1-KO MEFs were similar to those of JSAP1-KO MEFs and wild type MEFs, respectively. These results suggest that JSAP1 plays a role in adhesion and cell spreading by regulating the rapid reorganization of the actin cytoskeleton. © 2006 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | JSAP1 is required for the cell adhesion and spreading of mouse embryonic fibroblasts | - |
dc.type | Article | - |
dc.relation.issue | 2 | - |
dc.relation.volume | 345 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 809 | - |
dc.relation.lastpage | 816 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2006.05.005 | - |
dc.identifier.wosid | WOS:000238001600038 | - |
dc.identifier.scopusid | 2-s2.0-33646823300 | - |
dc.author.google | Chae H.-J. | - |
dc.author.google | Ha H.-Y. | - |
dc.author.google | Im J.-Y. | - |
dc.author.google | Song J.-Y. | - |
dc.author.google | Park S. | - |
dc.author.google | Han P.-L. | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |