Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이원재 | - |
dc.date.accessioned | 2018-05-18T08:15:26Z | - |
dc.date.available | 2018-05-18T08:15:26Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | OAK-2491 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243261 | - |
dc.description.abstract | We have investigated whether NAG-1 is induced in oral cavity cancer cells by various NSAIDs and if apoptosis induced by NSAIDs can be linked directly with the induction of NAG-1. NAG-1 expression was increased by diclofenac, aceclofenac, indomethacin, ibuprofen, and sulindac sulfide, in the order of NAG-1 induction, but not by acetaminophen, piroxicam or NS-398. Diclofenac was the most effective NAG-1 inducer. Incubation with diclofenac inhibited cell proliferation and induced apoptosis. The expression of NAG-1 was observed in advance of the induction of apoptosis. Conditioned medium from NAG-1-overexpressing Drosophila cells inhibited SCC 1483 cells proliferation and induced apoptosis. In summary, some NSAIDs induce NAG-1 expression in oral cavity cancer cells and the induced NAG-1 protein appears to mediate apoptosis. Therefore, NSAIDs may be considered as a possible chemopreventive agent against oral cavity cancer. © 2004 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.title | Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene | - |
dc.type | Article | - |
dc.relation.issue | 4 | - |
dc.relation.volume | 325 | - |
dc.relation.index | SCI | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 1298 | - |
dc.relation.lastpage | 1303 | - |
dc.relation.journaltitle | Biochemical and Biophysical Research Communications | - |
dc.identifier.doi | 10.1016/j.bbrc.2004.10.176 | - |
dc.identifier.wosid | WOS:000225557500026 | - |
dc.identifier.scopusid | 2-s2.0-8844231184 | - |
dc.author.google | Kim K.-S. | - |
dc.author.google | Yoon J.-H. | - |
dc.author.google | Kim J.K. | - |
dc.author.google | Baek S.J. | - |
dc.author.google | Eling T.E. | - |
dc.author.google | Lee W.J. | - |
dc.author.google | Ryu J.-H. | - |
dc.author.google | Lee J.G. | - |
dc.author.google | Lee J.-H. | - |
dc.author.google | Yoo J.-B. | - |
dc.contributor.scopusid | 이원재(57171092600) | - |
dc.date.modifydate | 20211210153636 | - |