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dc.contributor.author이원재-
dc.date.accessioned2018-05-18T08:15:26Z-
dc.date.available2018-05-18T08:15:26Z-
dc.date.issued2004-
dc.identifier.issn0006-291X-
dc.identifier.otherOAK-2491-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/243261-
dc.description.abstractWe have investigated whether NAG-1 is induced in oral cavity cancer cells by various NSAIDs and if apoptosis induced by NSAIDs can be linked directly with the induction of NAG-1. NAG-1 expression was increased by diclofenac, aceclofenac, indomethacin, ibuprofen, and sulindac sulfide, in the order of NAG-1 induction, but not by acetaminophen, piroxicam or NS-398. Diclofenac was the most effective NAG-1 inducer. Incubation with diclofenac inhibited cell proliferation and induced apoptosis. The expression of NAG-1 was observed in advance of the induction of apoptosis. Conditioned medium from NAG-1-overexpressing Drosophila cells inhibited SCC 1483 cells proliferation and induced apoptosis. In summary, some NSAIDs induce NAG-1 expression in oral cavity cancer cells and the induced NAG-1 protein appears to mediate apoptosis. Therefore, NSAIDs may be considered as a possible chemopreventive agent against oral cavity cancer. © 2004 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.titleCyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene-
dc.typeArticle-
dc.relation.issue4-
dc.relation.volume325-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1298-
dc.relation.lastpage1303-
dc.relation.journaltitleBiochemical and Biophysical Research Communications-
dc.identifier.doi10.1016/j.bbrc.2004.10.176-
dc.identifier.wosidWOS:000225557500026-
dc.identifier.scopusid2-s2.0-8844231184-
dc.author.googleKim K.-S.-
dc.author.googleYoon J.-H.-
dc.author.googleKim J.K.-
dc.author.googleBaek S.J.-
dc.author.googleEling T.E.-
dc.author.googleLee W.J.-
dc.author.googleRyu J.-H.-
dc.author.googleLee J.G.-
dc.author.googleLee J.-H.-
dc.author.googleYoo J.-B.-
dc.date.modifydate20180517113807-
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일반대학원 > 바이오융합과학과 > Journal papers
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