Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand

Abstract

Mono(trifluoroacetato)platinum(IV) complexes of the formula [Pt IV(dach)L 3(TFAc)] (dach = trans-(±)-1,2- diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt IV(dach)L 3(OH)] with trifluoroacetic anhydride in the presence of a base. Mono(trifluoroacetato) platinum(IV) complexes of the formula [Pt IV(dach)L 3(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt IV(dach)L 3(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED 50 = 3.1 μM) was found to be much higher than carboplatin (ED 50 = 10.2 μM). © 2004 Elsevier B.V. All rights reserved.