Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이지희 | * |
dc.contributor.author | 정영해 | * |
dc.date.accessioned | 2018-05-18T08:15:20Z | - |
dc.date.available | 2018-05-18T08:15:20Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 1465-993X | * |
dc.identifier.other | OAK-2547 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/243232 | - |
dc.description.abstract | Background: Although in vitro studies have determined that the activation of mitogen-activated protein (MAP) kinases is crucial to the activation of transcription factors and regulation of the production of proinflammatory mediators, the roles of c-Jun NH2-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in acute lung injury have not been elucidated. Methods: Saline or lipopolysaccharide (LPS, 6 mg/kg of body weight) was administered intratracheally with a 1-hour pretreatment with SP600125 (a JNK inhibitor; 30 mg/kg, IO), or PD98059 (an MEK/ERK inhibitor; 30 mg/kg, IO). Rats were sacrificed 4 hours after LPS treatment. Results: SP600125 or PD98059 inhibited LPS-induced phosphorylation of JNK and ERK, total protein and LDH activity in BAL fluid, and neutrophil influx into the lungs. In addition, these MAP kinase inhibitors substantially reduced LPS-induced production of inflammatory mediators, such as CINC, MMP-9, and nitric oxide. Inhibition of JNK correlated with suppression of NF-κB activation through downregulation of phosphorylation and degradation of IκB-α, while ERK inhibition only slightly influenced the NF-κB pathway. Conclusion: JNK and ERK play pivotal roles in LPS-induced acute lung injury. Therefore, inhibition of JNK or ERK activity has potential as an effective therapeutic strategy in interventions of inflammatory cascade-associated lung injury. © 2004 Lee et al; licensee BioMed Central Ltd. | * |
dc.language | English | * |
dc.title | Inhibition of c-Jun NH2-terminal kinase or extracellular signal-regulated kinase improves lung injury | * |
dc.type | Article | * |
dc.relation.volume | 5 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Respiratory Research | * |
dc.identifier.doi | 10.1186/1465-9921-5-23 | * |
dc.identifier.wosid | WOS:000226241300001 | * |
dc.identifier.scopusid | 2-s2.0-20044394273 | * |
dc.author.google | Lee H.S. | * |
dc.author.google | Kim H.J. | * |
dc.author.google | Moon C.S. | * |
dc.author.google | Chong Y.H. | * |
dc.author.google | Kang J.L. | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 정영해(7201371824) | * |
dc.date.modifydate | 20240116125728 | * |