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Oxidative stress-related gene polymorphism and the risk of preeclampsia
- Oxidative stress-related gene polymorphism and the risk of preeclampsia
- Kim Y.J.; Park H.S.; Park M.H.; Suh S.H.; Pang M.-G.
- Ewha Authors
- 김영주; 서석효; 박혜숙; 박미혜
- SCOPUS Author ID
- 김영주; 서석효; 박혜숙; 박미혜
- Issue Date
- Journal Title
- European Journal of Obstetrics Gynecology and Reproductive Biology
- European Journal of Obstetrics Gynecology and Reproductive Biology vol. 119, no. 1, pp. 42 - 46
- SCI; SCIE; SCOPUS
- Document Type
- Objective: The purpose of this study was to determine whether genetic variability in oxidative stress-related enzymes contributes to individual preeclampsia susceptibility differences. Study Design: Polymorphisms in the cytochrome P450 (CYP)1A1 (MspI), CYP1A1(Ile/Val), glutathione S-transferase (GST)M1, GSTT1, myeloperoxidase (MPO), and manganese superoxide dismutase (MnSOD) genes were evaluated by polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (RFLP) in 214 healthy controls with an uncomplicated obstetric history, and in 121 preeclampsia patients. χ2 analyses were used to statistically evaluate differences. Results: No significant differences in the CYP1A1(MspI) or CYP1A1(Ile/Val) genotypes were observed between the healthy controls and the preeclampsia patients (χ2 = 1.43, P = 0.49 versus χ2 = 1.54, P = 0.46). The GSTM1 homozygous null type and GSTT1 homozygous null type were no differences in the patients and controls (χ2 = 0.01, P = 0.92 versus χ2 = 0.31, P = 0.57), and no significant differences in the polymorphisms of the MPO and MnSOD genotypes were found between the patients and controls (χ2 = 2.00, P = 0.37 versus χ2 = 0.07, P = 0.96). Conclusion: Polymorphisms in the oxidative stress-related genes (CYP1A1, GSTM1, GSTT1, MPO, MnSOD) do not seem to be risk factors for preeclampsia. © 2004 Published by Elsevier Ireland Ltd.
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