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A unifying pathway for essential hypertension
- Title
- A unifying pathway for essential hypertension
- Authors
- Johnson R.J.; Rodriguez-Iturbe B.; Kang D.-H.; Feig D.I.; Herrera-Acosta J.
- Ewha Authors
- 강덕희
- SCOPUS Author ID
- 강덕희
- Issue Date
- 2005
- Journal Title
- American Journal of Hypertension
- ISSN
- 0895-7061
- Citation
- American Journal of Hypertension vol. 18, no. 3, pp. 431 - 440
- Indexed
- SCI; SCIE; SCOPUS
- Document Type
- Review
- Abstract
- We present the hypothesis that most cases of essential hypertension occur via two phases. The first phase is initiated by episodes of renal vasoconstriction induced by a hyperactive sympathetic nervous system, activation of the renin-angiotensin system, or hyperuricemia resulting from diet or genetics. During this phase the hypertension is salt resistant and renin dependent, and the kidney normal. Over time, preglomerular vascular disease develops (arteriolosclerosis), associated with tubulointerstitial inflammation; this shifts the hypertension to a salt-sensitive, volume-dependent, and renal-dependent pathway. This pathway unites many of the previous hypotheses on the etiology of hypertension, and offers insights into ways to prevent, ameliorate, or cure the underlying process. © 2005 American Journal of Hypertension, Ltd.
- DOI
- 10.1016/j.amjhyper.2004.08.035
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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