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Pseudoeosinophilia associated with malaria infection determined in the Sysmex XE-2100 hematology analyzer

Title
Pseudoeosinophilia associated with malaria infection determined in the Sysmex XE-2100 hematology analyzer
Authors
Huh J.Jung J.Yoon H.Chung W.
Ewha Authors
정화순허정원
SCOPUS Author ID
정화순scopus; 허정원scopus
Issue Date
2005
Journal Title
Annals of Hematology
ISSN
0939-5555JCR Link
Citation
vol. 84, no. 6, pp. 400 - 402
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Hemozoin is known to be an end product of hemoglobin digestion by the malaria parasite. Hemozoin is a birefringent crystal, and thus hemozoin-containing white blood cells (WBCs) may show the atypical light scattering pattern. The purpose of this study was to investigate pseudoeosinophilia associated with malaria infection using a Sysmex XE-2100 hematology analyzer (Sysmex Corporation, Kobe, Japan). The study group included 16 patients with malaria infection. Of these, 38% showed erroneously high eosinophil counts and atypical eosinophil distributions in the WBCs scattergram, which was due to the presence of hemozoin-containing neutrophils. In two patients, their erroneously high eosinophil counts declined as the parasitemia decreased with treatment. In conclusion, hematologists should consider the possibility of pseudoeosinophilia as a result of hemozoin-containing WBCs and confirm the WBC differential count by microscopy in cases of malaria infection. © Springer-Verlag 2004.
DOI
10.1007/s00277-004-0987-z
Appears in Collections:
의학전문대학원 > 의학과 > Theses_Master
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