View : 25 Download: 0

The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities

Title
The high incidence of meiotic errors increases with decreased sperm count in severe male factor infertilities
Authors
Pang M.-G.Kim Y.J.Lee S.-H.Kim C.-K.
Ewha Authors
김영주
SCOPUS Author ID
김영주scopus
Issue Date
2005
Journal Title
Human Reproduction
ISSN
0268-1161JCR Link
Citation
Human Reproduction vol. 20, no. 6, pp. 1688 - 1694
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background: The high frequency of aneuploidy sperm raises concerns that there may be an increased incidence of aneuploid offspring in ICSI programmes. In order to assess the role that chromosome complement plays in normal and abnormal fertility, detailed molecular cytogenetic studies must be done on sperm samples from men with normal and abnormal fertility. Methods: To understand more clearly the cytogenetic make-up of sperm from oligoasthenoteratozoospermic (OAT) patients, multi-colour fluorescence in situ hybridization was used to determine numerical chromosome abnormalities. Results: Increased aneuploidy frequencies for chromosomes 13, 18, 21, X and Y were detected in sperm from OAT patients. The frequencies of diploidy also increased. There were no differences in non-disjunction at meiosis I compared to meiosis II. Sperm count inversely correlated with the frequencies of diploidy, aneuploidies for chromosomes 13 and 21 in OAT patients. Twenty-two cycles of ICSI and 18 embryo transfers were performed in 20 couples. Only three cases achieved successful pregnancies. Conclusions: A higher incidence of meiotic errors and lower sperm counts was found in sperm from OAT patients. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
DOI
10.1093/humrep/deh817
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE