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Synthesis and antifungal activity of naphthalene-1,4-diones modified at positions 2, 3, and 5
- Title
- Synthesis and antifungal activity of naphthalene-1,4-diones modified at positions 2, 3, and 5
- Authors
- Ryu C.-K.; Mi J.C.
- Ewha Authors
- 유충규
- SCOPUS Author ID
- 유충규
- Issue Date
- 2005
- Journal Title
- Archives of Pharmacal Research
- ISSN
- 0253-6269
- Citation
- Archives of Pharmacal Research vol. 28, no. 7, pp. 750 - 755
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- A series of 2-arylamino-5-hydroxy-naphthalene-1,4-diones, 3-arylamino-5-methoxy-naphthalene-1,4-diones, and 2-arylamino-3chloro-5-hydroxy- naphthalene-1,4-diones were synthesized and tested for in vitro antifungal activity against the species Candida and Aspergillus niger. Among those tested, 3-arylamino-5-methoxy-naphthalene-1,4-diones exhibited potent antifungal activity. In general, the 3-arylamino-5-methoxy-naphthalene-1,4-diones showed more potent antifungal activity than the 2-arylamino-5-hydroxy-naphthalene-1,4- diones and the 2-arylamino-3-chloro-5-hydroxy-naphthalene-1,4-diones.
- DOI
- 10.1007/BF02977337
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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