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1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor

Title
1,2,3,4,6-Penta-O-galloyl-beta-D-glucose blocks endothelial cell growth and tube formation through inhibition of VEGF binding to VEGF receptor
Authors
Lee S.-J.Lee H.M.Ji S.-T.Lee S.-R.Mar W.Gho Y.S.
Ewha Authors
이승록
Issue Date
2004
Journal Title
Cancer Letters
ISSN
0304-3835JCR Link
Citation
vol. 208, no. 1, pp. 89 - 94
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors. Vascular endothelial growth factor (VEGF) is the most important angiogenic molecule associated with tumor-induced neovascularization. VEGF exerts its activity through binding to its receptor tyrosine kinase, KDR/Flk-1, expressed on the surface of endothelial cells. From the screening of medicinal plants, we have identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from the roots of Paeonia lactiflora that inhibited the binding of VEGF to KDR/Flk-1. PGG efficiently blocked VEGF-induced human umbilical vein endothelial cell proliferation and the growth of immortalized human microvascular endothelial cells, but did not affect the growth of HT1080 human fibrosarcoma and DU-145 human prostate carcinoma cells. PGG also blocked VEGF-induced capillary-like tube formation of endothelial cell on Matrigel. Our results suggest that PGG could be a candidate for developing anti-angiogenic agent. © 2003 Elsevier Ireland Ltd. All rights reserved.
DOI
10.1016/j.canlet.2003.11.008
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자연과학대학 > 생명과학전공 > Journal papers
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