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Sarcomatoid hepatocellular carcinoma with hepatoblastoma-like features in an adult

Title
Sarcomatoid hepatocellular carcinoma with hepatoblastoma-like features in an adult
Authors
Cho M.-S.Lee S.N.Sung S.H.Han W.S.
Ewha Authors
이시내한운섭성순희조민선
SCOPUS Author ID
한운섭scopusscopus; 성순희scopus; 조민선scopus
Issue Date
2004
Journal Title
Pathology International
ISSN
1320-5463JCR Link
Citation
Pathology International vol. 54, no. 6, pp. 446 - 450
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A mixed epithelial and mesenchymal tumor of the liver arising in an adult is rare and is mostly classified as sarcomatoid hepatocellular carcinoma (HCC). In this study, a case of sarcomatoid HCC in an adult with hepatoblastoma (HB)-like features, which produced difficulty in the differential diagnosis between sarcomatoid HCC and mixed HB, is presented. The epithelial component of the tumor composed of poorly differentiated HCC, Edmondson's grade III, and more primitive components, which were embryonal and small cell undifferentiated components of HB-like areas. The small undifferentiated cells surrounded HCC and the embryonal component of HB-like area, and revealed transition partly to areas of rhabdomyosarcoma. A small portion of chondrosarcoma was also noted. Immunohistochemical analysis showed that HCC and the embryonal component of HB-like areas expressed alpha-fetoprotein (AFP) and cytokeratin 8. The small undifferentiated cells were negative for AFP but stained with cytokeratin 8 as well as CD56, which is a marker of primitive cells in many sarcoma and HB. It is not certain whether small undifferentiated cells belong to hepatic progenitor cells or primitive mesenchymal cells. Polymerase chain reaction-single-strand conformation polymorphism analysis for beta-catenin mutation using microdissection revealed no mutation of any components. A review was undertaken of the cases previously reported as adult hepatoblastoma without detailed immunohistochemical study and consider many of them may be sarcomatoid HCC.These primitive and sarcomatoid components would be arising from the dedifferentiation process of HCC.
DOI
10.1111/j.1440-1827.2004.01640.x
Appears in Collections:
의과대학 > 의학과 > Journal papers
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