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Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis

Title
Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis
Authors
Yoon K.Jang H.D.Lee S.Y.
Ewha Authors
이수영
SCOPUS Author ID
이수영scopusscopus
Issue Date
2004
Journal Title
Biochemical and Biophysical Research Communications
ISSN
0006-291XJCR Link
Citation
Biochemical and Biophysical Research Communications vol. 319, no. 2, pp. 649 - 654
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Second mitochondria-derived activator of caspase (Smac) has been implicated in the activation of apoptosis in response to cell stress. We screened for Smac/DIABLO-binding protein for further understanding of Smac-mediated apoptosis. We identified NADE, previously known as p75NTR-associated cell death executor, as a Smac-binding protein. Smac-NADE interaction was mapped to the N-terminal region of Samc and the C-terminal region of NADE. Co-expression of NADE and Smac promotes TRAIL-induced apoptosis in MCF-7 cells. Interestingly, the co-presence of Smac and NADE inhibits XIAP-mediated Smac ubiquitination. In conclusion, our results provide the first evidence that the interaction between Smac and NADE regulates apoptosis through the inhibition of Smac ubiquitination. © 2004 Elsevier Inc. All rights reserved.
DOI
10.1016/j.bbrc.2004.05.043
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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