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Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g] phthalazine-4,9-dione derivatives

Title
Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g] phthalazine-4,9-dione derivatives
Authors
Sung Kim J.Lee H.-J.Suh M.-E.Choo H.-Y.P.Lee S.K.Park H.J.Kim C.Park S.W.Lee C.-O.
Ewha Authors
김춘미박혜영이상국
SCOPUS Author ID
김춘미scopus; 박혜영scopus
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry
ISSN
0968-0896JCR Link
Citation
Bioorganic and Medicinal Chemistry vol. 12, no. 13, pp. 3683 - 3686
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin. © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmc.2004.04.014
Appears in Collections:
약학대학 > 약학과 > Journal papers
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