Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이서구 | * |
dc.contributor.author | 배윤수 | * |
dc.date.accessioned | 2018-05-02T08:15:29Z | - |
dc.date.available | 2018-05-02T08:15:29Z | - |
dc.date.issued | 2004 | * |
dc.identifier.issn | 0960-0760 | * |
dc.identifier.other | OAK-2312 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242710 | - |
dc.description.abstract | Ischemia and simulated ischemic conditions cause intracellular Ca 2+ overload in the myocardium. The relationship between ischemia injury and Ca2+ overload has not been fully characterized. The aim of the present study was to investigate the expression and characteristics of PLC isozymes in myocardial infarction-induced cardiac remodeling and heart failure. In normal rat heart tissue, PLC-δ1 (about 44 ng/mg of heart tissue) was most abundant isozymes compared to PLC-γ1 (6.8 ng/mg) and PLC-β1 (0.4 ng/mg). In ischemic heart and hypoxic neonatal cardiomyocytes, PLC-δ1, but not PLC-β1 and PLC-γ1, was selectively degraded, a response that could be inhibited by the calpain inhibitor, calpastatin, and by the caspase inhibitor, zVAD-fmk. Overexpression of the PLC-δ1 in hypoxic neonatal cardiomyocytes rescued intracellular Ca2+ overload by ischemic conditions. In the border zone and scar region of infarcted myocardium, and in hypoxic neonatal cardiomyocytes, the selective degradation of PLC-δ1 by the calcium sensitive proteases may play important roles in intracellular Ca2+ regulations under the ischemic conditions. It is suggested that PLC isozyme-changes may contribute to the alterations in calcium homeostasis in myocardial ischemia. © 2004 Elsevier Ltd. All rights reserved. | * |
dc.language | English | * |
dc.title | Phospholipase C-δ1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 91 | * |
dc.relation.index | SCI | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 131 | * |
dc.relation.lastpage | 138 | * |
dc.relation.journaltitle | Journal of Steroid Biochemistry and Molecular Biology | * |
dc.identifier.doi | 10.1016/j.jsbmb.2004.02.009 | * |
dc.identifier.wosid | WOS:000223419600004 | * |
dc.identifier.scopusid | 2-s2.0-3342943322 | * |
dc.author.google | Hwang K.-C. | * |
dc.author.google | Lim S. | * |
dc.author.google | Kwon H.M. | * |
dc.author.google | Bae Y.S. | * |
dc.author.google | Kang S.-M. | * |
dc.author.google | Chung K.-H. | * |
dc.author.google | Graham R.M. | * |
dc.author.google | Rhee S.G. | * |
dc.author.google | Jang Y. | * |
dc.contributor.scopusid | 이서구(7401852092) | * |
dc.contributor.scopusid | 배윤수(15031067200) | * |
dc.date.modifydate | 20240423081003 | * |