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dc.contributor.author이서구-
dc.contributor.author배윤수-
dc.date.accessioned2018-05-02T08:15:29Z-
dc.date.available2018-05-02T08:15:29Z-
dc.date.issued2004-
dc.identifier.issn0960-0760-
dc.identifier.otherOAK-2312-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/242710-
dc.description.abstractIschemia and simulated ischemic conditions cause intracellular Ca 2+ overload in the myocardium. The relationship between ischemia injury and Ca2+ overload has not been fully characterized. The aim of the present study was to investigate the expression and characteristics of PLC isozymes in myocardial infarction-induced cardiac remodeling and heart failure. In normal rat heart tissue, PLC-δ1 (about 44 ng/mg of heart tissue) was most abundant isozymes compared to PLC-γ1 (6.8 ng/mg) and PLC-β1 (0.4 ng/mg). In ischemic heart and hypoxic neonatal cardiomyocytes, PLC-δ1, but not PLC-β1 and PLC-γ1, was selectively degraded, a response that could be inhibited by the calpain inhibitor, calpastatin, and by the caspase inhibitor, zVAD-fmk. Overexpression of the PLC-δ1 in hypoxic neonatal cardiomyocytes rescued intracellular Ca2+ overload by ischemic conditions. In the border zone and scar region of infarcted myocardium, and in hypoxic neonatal cardiomyocytes, the selective degradation of PLC-δ1 by the calcium sensitive proteases may play important roles in intracellular Ca2+ regulations under the ischemic conditions. It is suggested that PLC isozyme-changes may contribute to the alterations in calcium homeostasis in myocardial ischemia. © 2004 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.titlePhospholipase C-δ1 rescues intracellular Ca2+ overload in ischemic heart and hypoxic neonatal cardiomyocytes-
dc.typeArticle-
dc.relation.issue3-
dc.relation.volume91-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage131-
dc.relation.lastpage138-
dc.relation.journaltitleJournal of Steroid Biochemistry and Molecular Biology-
dc.identifier.doi10.1016/j.jsbmb.2004.02.009-
dc.identifier.wosidWOS:000223419600004-
dc.identifier.scopusid2-s2.0-3342943322-
dc.author.googleHwang K.-C.-
dc.author.googleLim S.-
dc.author.googleKwon H.M.-
dc.author.googleBae Y.S.-
dc.author.googleKang S.-M.-
dc.author.googleChung K.-H.-
dc.author.googleGraham R.M.-
dc.author.googleRhee S.G.-
dc.author.googleJang Y.-
dc.contributor.scopusid이서구(7401852092;25923074700)-
dc.contributor.scopusid배윤수(15031067200)-
dc.date.modifydate20190901081003-
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