NL repository
menu
검색
Library
Browse
Communities & Collections
By Date
Authors
Titles
Subject
My Repository
My Account
Receive email updates
Edit Profile
DSpace at EWHA
의과대학
의학과
Journal papers
View : 472 Download: 0
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
Title
Synthesis and antitumor activity of 4-hydroxycoumarin derivatives
Authors
Jung J.-C.
;
Lee J.-H.
;
Oh S.
;
Lee J.-G.
;
Park O.-S.
Ewha Authors
오세관
SCOPUS Author ID
오세관
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894X
Citation
Bioorganic and Medicinal Chemistry Letters vol. 14, no. 22, pp. 5527 - 5531
Indexed
SCI; SCIE; SCOPUS
Document Type
Article
Abstract
A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity against five human tumor cell lines. A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity. © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2004.09.009
Appears in Collections:
의과대학
>
의학과
>
Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show full item record
Find@EWHA
트윗하기
BROWSE
Communities & Collections
By Date
Authors
Titles
Subject