Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E 2 production in lipopolysaccharide-induced mouse macrophage cells

Abstract

The inhibitory effects of pinosylvin analogues on the production of COX-2 mediated PGE 2 were evaluated in a cell culture system. A new series of potential inhibitors, including 3-hydroxy-5-benzyloxy-trans-stilbene and 3,5-dimethoxy-trans-stilbene, have been identified. A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E 2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents. © 2004 Elsevier Ltd. All rights reserved.