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Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E 2 production in lipopolysaccharide-induced mouse macrophage cells

Title
Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E 2 production in lipopolysaccharide-induced mouse macrophage cells
Authors
Park E.-J.Min H.-Y.Ahn Y.-H.Bae C.-M.Pyee J.-H.Lee S.K.
Ewha Authors
이상국
Issue Date
2004
Journal Title
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894XJCR Link
Citation
Bioorganic and Medicinal Chemistry Letters vol. 14, no. 23, pp. 5895 - 5898
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The inhibitory effects of pinosylvin analogues on the production of COX-2 mediated PGE 2 were evaluated in a cell culture system. A new series of potential inhibitors, including 3-hydroxy-5-benzyloxy-trans-stilbene and 3,5-dimethoxy-trans-stilbene, have been identified. A series of natural stilbenoids, pinosylvin and its derivatives, were synthesized and evaluated for the inhibitory activity of prostaglandin E 2 production in lipopolysaccharide-induced RAW 264.7 cells. Potential inhibitors, including 3,5-dimethoxy-trans-stilbene and 3-hydroxy-5-benzyloxy-trans-stilbene, have been newly identified, and thus providing chemical leads for the further development of anti-inflammatory or cancer chemopreventive agents. © 2004 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.bmcl.2004.09.022
Appears in Collections:
약학대학 > 약학과 > Journal papers
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