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Early-onset mild cognitive impairment in Parkinson's disease: Altered corticopetal cholinergic network

Title
Early-onset mild cognitive impairment in Parkinson's disease: Altered corticopetal cholinergic network
Authors
Kim, InjoongShin, Na-YoungBak, YunjinLee, Phil HyuLee, Seung-KooLim, Soo Mee
Ewha Authors
임수미
SCOPUS Author ID
임수미scopus
Issue Date
2017
Journal Title
SCIENTIFIC REPORTS
ISSN
2045-2322JCR Link
Citation
vol. 7
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Degeneration of the substantia innominata (SI) is significantly correlated with cognitive performance in Parkinson's disease (PD). We examined functional and structural patterns of SI degeneration in drug-naive PD patients according to the duration of parkinsonism before mild cognitive impairment (MCI) diagnosis. Twenty PD patients with a shorter duration (PD-MCI-SD, < 1 year), 18 patients with a longer duration (PD-MCI-LD, >= 1 year), and 29 patients with intact cognition (PD-IC) were included. Seed-based resting-state functional connectivity (rsFC) analysis using bilateral SI seed and region-of-interest-based volumetric analysis were performed. Compared to PD-IC, the collapsed PD-MCI group showed altered rsFC in the right frontal and bilateral parietal areas. PD-MCI-SD showed rsFC alteration in broader frontal and parietal areas compared to the other groups. Decreased rsFC in the right frontal area was also significantly correlated with shorter disease duration. No significant SI volume change was found between the groups. Altered rsFC between the SI and the frontal and parietal areas might be relevant to cognitive dysfunction in PD. Decreased rsFC between the SI and frontal area might be associated with early-onset MCI, suggesting that cholinergic deficits in the frontal brain areas might play an important role in the acceleration of cognitive decline in PD.
DOI
10.1038/s41598-017-02420-w
Appears in Collections:
의과대학 > 의학과 > Journal papers
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