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dc.contributor.author최선-
dc.contributor.author차선신-
dc.date.accessioned2018-04-25T08:13:39Z-
dc.date.available2018-04-25T08:13:39Z-
dc.date.issued2018-
dc.identifier.issn0141-8130-
dc.identifier.issn1879-0003-
dc.identifier.otherOAK-21873-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/242573-
dc.description.abstractThe DJ-1 protein engages in diverse cellular and pathological processes, including tumorigenesis, apoptosis, sperm fertilization, and the progression of Parkinson's disease (PD). The functional dimeric form of DJ-1 transforms into non-functional filamentous aggregates in an inorganic phosphate (P-1)-dependent manner in vitro. Here, we demonstrated that P-i and reactive oxygen species (ROS) induce DJ-1 aggregation in Neuro2A and SH-SY5Y cells. Remarkably, tartrate treatment significantly reduced P-i- and ROS-induced DJ-1 aggregation and restored P-i- and ROS-provoked cell death using quantitative data as mean +/- standard deviation, and statistics. Mechanistically, tartrate prevented DJ-1 aggregation via occupying the P-i-binding site. These findings revealed an unexpected physiological role of tartrate in the maintenance of DJ-1 function, and thus, a potential use as an inhibitor of DJ-1 aggregation. (C) 2017 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectTartrate-
dc.subjectDJ-1-
dc.subjectParkinson's disease-
dc.subjectInorganic phosphate-
dc.subjectROS-
dc.titleInhibitory effect of tartrate against phosphate-induced DJ-1 aggregation-
dc.typeArticle-
dc.relation.volume107-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage1650-
dc.relation.lastpage1658-
dc.relation.journaltitleINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES-
dc.identifier.doi10.1016/j.ijbiomac.2017.10.022-
dc.identifier.wosidWOS:000424062300032-
dc.identifier.scopusid2-s2.0-85031501683-
dc.author.googleKim, Min Soo-
dc.author.googleLee, Sangmin-
dc.author.googleYun, Sanguk-
dc.author.googleSuh, Pann-Ghill-
dc.author.googlePark, Jongmi-
dc.author.googleCui, Minghua-
dc.author.googleChoi, Sun-
dc.author.googleCha, Sun-Shin-
dc.author.googleJin, Wook-
dc.contributor.scopusid최선(8659831000)-
dc.contributor.scopusid차선신(56883751800)-
dc.date.modifydate20180517105337-
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약학대학 > 약학과 > Journal papers
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