View : 115 Download: 0
Serum persistent organic pollutants levels and stroke risk
- Serum persistent organic pollutants levels and stroke risk
- Lim, Jung-eun; Lee, Sunju; Lee, Sunmi; Jee, Sun Ha
- Ewha Authors
- Issue Date
- Journal Title
- ENVIRONMENTAL POLLUTION
- ENVIRONMENTAL POLLUTION vol. 233, pp. 855 - 861
- Stroke; Endocrine disruptors; Polychlorinated biphenyls; Prospective studies
- ELSEVIER SCI LTD
- SCI; SCIE; SCOPUS
- Document Type
- Knowledge of environmental risk factors for stroke and their role are limited. We performed a case cohort study to evaluate the association between serum persistent organic pollutants (POPs) level and stroke risk. 526 subcohort members and 111 stroke incidence cases were identified from the Korean Cancer Prevention Study-II. Serum levels of POPs were measured using gas chromatography/high-resolution mass spectrometry. The hazard ratios (HRs) for stroke (ischemic, hemorrhagic, and all stroke types) were estimated using the weighted Cox regression model. Age, sex, body mass index, smoking status, physical activity, family history of cardiovascular disease, and hypertension were adjusted in the weighted Cox regression model. After adjusting for potential confounding factors, increased risk for stroke was observed among participants with serum concentration of p,p'-DDE in the highest tertile compared to those in the lowest tertile (HR = 4.10, 95% CI: 1.58,10.59). A similar association was estimated for PCB118 (HR = 2.33, 95% CI: 1.04, 5.22), PCB156 (HR = 3.42, 95% CI: 1.42, 8.23), and PCB138 (HR = 3.80, 95% CI: 1.48, 9.76). For TEQ, stroke was three times as likely to occur among subjects with TEQ in the highest tertile compared to those in the lowest tertile (HR = 3.12, 95% CI: 1.27, 7.65). PCBs were positively associated with ischemic stroke, but not with hemorrhagic stroke. Elevated serum POPs levels were associated with an increased risk of stroke, especially ischemic stroke. (C) 2017 Elsevier Ltd. All rights reserved.
- Appears in Collections:
- 일반대학원 > 제약산업학과 > Theses_Master
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.