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Serum persistent organic pollutants levels and stroke risk

Title
Serum persistent organic pollutants levels and stroke risk
Authors
Lim, Jung-eunLee, SunjuLee, SunmiJee, Sun Ha
Ewha Authors
임정은
Issue Date
2018
Journal Title
ENVIRONMENTAL POLLUTION
ISSN
0269-7491JCR Link

1873-6424JCR Link
Citation
ENVIRONMENTAL POLLUTION vol. 233, pp. 855 - 861
Keywords
StrokeEndocrine disruptorsPolychlorinated biphenylsProspective studies
Publisher
ELSEVIER SCI LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Knowledge of environmental risk factors for stroke and their role are limited. We performed a case cohort study to evaluate the association between serum persistent organic pollutants (POPs) level and stroke risk. 526 subcohort members and 111 stroke incidence cases were identified from the Korean Cancer Prevention Study-II. Serum levels of POPs were measured using gas chromatography/high-resolution mass spectrometry. The hazard ratios (HRs) for stroke (ischemic, hemorrhagic, and all stroke types) were estimated using the weighted Cox regression model. Age, sex, body mass index, smoking status, physical activity, family history of cardiovascular disease, and hypertension were adjusted in the weighted Cox regression model. After adjusting for potential confounding factors, increased risk for stroke was observed among participants with serum concentration of p,p'-DDE in the highest tertile compared to those in the lowest tertile (HR = 4.10, 95% CI: 1.58,10.59). A similar association was estimated for PCB118 (HR = 2.33, 95% CI: 1.04, 5.22), PCB156 (HR = 3.42, 95% CI: 1.42, 8.23), and PCB138 (HR = 3.80, 95% CI: 1.48, 9.76). For TEQ, stroke was three times as likely to occur among subjects with TEQ in the highest tertile compared to those in the lowest tertile (HR = 3.12, 95% CI: 1.27, 7.65). PCBs were positively associated with ischemic stroke, but not with hemorrhagic stroke. Elevated serum POPs levels were associated with an increased risk of stroke, especially ischemic stroke. (C) 2017 Elsevier Ltd. All rights reserved.
DOI
10.1016/j.envpol.2017.12.031
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일반대학원 > 제약산업학과 > Theses_Master
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