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Application of differentiated human tonsil-derived stem cells to trembler-J mice

Title
Application of differentiated human tonsil-derived stem cells to trembler-J mice
Authors
Park, SaeyoungChoi, YoonyoungKwak, GeonHong, Young BinJung, NamheeKim, JieunChoi, Byung-okJung, Sung-Chul
Ewha Authors
정성철
SCOPUS Author ID
정성철scopus
Issue Date
2018
Journal Title
MUSCLE & NERVE
ISSN
0148-639XJCR Link

1097-4598JCR Link
Citation
MUSCLE & NERVE vol. 57, no. 3, pp. 478 - 486
Keywords
Charcot-Marie-Tooth diseaseneuromuscularregenerationstem cell therapytonsil-derived MSCstrembler-J mice
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
IntroductionMesenchymal stem cells (MSCs) can differentiate into various cell types. MethodsIn this study we investigated the potential of human tonsil-derived MSCs (T-MSCs) for neuromuscular regeneration in trembler-J (Tr-J) mice, a model for Charcot-Marie-Tooth disease type 1A (CMT1A). ResultsT-MSCs differentiated toward skeletal myocytes with increased expression of skeletal muscle-related markers (including troponin I type 1, and myogenin), and the formation of myotubes in vitro. In-situ transplantation of T-MSC-derived myocytes (T-MSC myocytes) into the gastrocnemius muscle in Tr-J mice enhanced motor function, with recovery of compound muscle action potential amplitudes. Morphology of the sciatic nerve and skeletal muscle recovered without the formation of teratomas, and the expression levels of nerve growth factor and glial-cell-line-derived neurotrophic factor were increased significantly in T-MSC myocytes compared with T-MSCs in vitro. DiscussionTransplantation of T-MSC myocytes could enable neuromuscular regeneration in patients with CMT1A. Muscle Nerve57: 478-486, 2018
DOI
10.1002/mus.25763
Appears in Collections:
의과대학 > 의학과 > Journal papers
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