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Preventive effects of tonsil-derived mesenchymal stem cells on osteoradionecrosis in a rat model
- Title
- Preventive effects of tonsil-derived mesenchymal stem cells on osteoradionecrosis in a rat model
- Authors
- Park, Hae Sang; Lee, Jihae; Kim, Jin-Woo; Kim, Ha Young; Jung, Soo Yeon; Lee, Sung Min; Park, Chan Hum; Kim, Han Su
- Ewha Authors
- 김한수; 김진우; 정수연
- SCOPUS Author ID
- 김한수; 김진우; 정수연
- Issue Date
- 2018
- Journal Title
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- ISSN
- 1043-3074
1097-0347
- Citation
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK vol. 40, no. 3, pp. 526 - 535
- Keywords
- animal model; cell therapy; mesenchymal stem cell; osteoradionecrosis; tonsils
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- BackgroundThe purpose of this study was to investigate the effects of tonsil-derived mesenchymal stem cells (MSCs) on osteoradionecrosis (ORN). MethodWe generated a mandibular ORN rat model using a combination of 20-Gy single-dose irradiation and tooth extraction. Study groups were negative control (tooth extraction only), ORN group (irradiation, tooth extraction), Matrigel-1 group (Matrigel; BD Biosciences, San Jose, CA; irradiation, Matrigel application immediately after tooth extraction), tonsil-derived MSC-1 group (irradiation, tonsil-derived MSC application immediately after tooth extraction), Matrigel-4 group (irradiation, Matrigel application 4 weeks after tooth extraction), and tonsil-derived MSC-4 group (irradiation, tonsil-derived MSC application 4 weeks after tooth extraction). ResultBone mineral density was significantly lower in the ORN group than in the negative control group. The tonsil-derived MSC-1 group showed significantly higher bone mineral density than did the ORN and tonsil-derived MSC-4 groups. ConclusionA single 20-Gy dose of irradiation combined with tooth extraction successfully generated ORN in the rat model. The tonsil-derived MSCs can be effective for bone regeneration in ORN, particularly when applied immediately after dentoalveolar trauma or surgery.
- DOI
- 10.1002/hed.25004
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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