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Clinical course of asthma patients with H1N1 influenza infection and oseltamivir

Title
Clinical course of asthma patients with H1N1 influenza infection and oseltamivir
Authors
Kim, Min-HyeSong, Woo-JungYang, Min-SukLee, So-HeeKwon, Jae-WooKim, Sae-HoonKang, Hye-RyunPark, Heung-WooHo, Young-Joo C.Cho, Sang-HeonMin, Kyung-UpKim, You-YoungChang, Yoon-Seok
Ewha Authors
조영주김민혜
SCOPUS Author ID
조영주scopus; 김민혜scopus
Issue Date
2018
Journal Title
MINERVA MEDICA
ISSN
0026-4806JCR Link

1827-1669JCR Link
Citation
MINERVA MEDICA vol. 109, no. 1, pp. 7 - 14
Keywords
Influenza A virus, H1N1 subtype; Asthma; Oseltamivir; Respiratory tract infections
Publisher
EDIZIONI MINERVA MEDICA
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
BACKGROUND: H1N1 influenza virus prevailed throughout the world in 2009. However, there are few reports on the clinical features of H1N1 influenza infection in adult asthma patients. We evaluated the clinical features in asthma patients with H1N1 influenza infection who took oseltamivir and compared them to those with other upper respiratory infections. METHODS: We reviewed asthma patients over 15 years of age who had visited Seoul National University Hospital and Seoul National University Bundang Hospital for suspected H1N1 influenza infection from August 2009 to March 2010. Various clinical features such as hospital admission days, respiratory symptoms, basal lung function, and past history was compared between H1N1 influenza PCR positive and negative groups. RESULTS: A total of 111 asthmatics were enrolled. All patients took oseltamivir. H1N1 RT-PCR was positive in 62 patients (55.9%), negative in 49 patients (44.1%). Wheezing developed more frequently in the H1N1 positive group. (43.5 vs. 16.7%, P=0.044). The rate of acute asthma exacerbations and pneumonia development were higher in the H1N1 positive group (59.7 vs. 51%, P=0.015, 25.0% vs. 0%, P<0.001). The rates for emergency room visit, hospital admissions, intensive care unit admissions, hospital days were not different between the groups. Underlying medical conditions were accompanied more frequently in the H1N1 negative patients (21.6% vs. 30.6%, P=0.002), especially cardiac disease (7.2% vs. 15.3%, P=0.011). CONCLUSIONS: H1N1 influenza infection may affect the clinical course of asthma combined with more severe manifestations; however, Oseltamivir could have affected the clinical course of H1N1 infected patients and made it milder than expected.
DOI
10.23736/S0026-4806.17.05329-0
Appears in Collections:
의과대학 > 의학과 > Journal papers
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