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Effects of traffic-related air pollution on susceptibility to infantile bronchiolitis and childhood asthma: A cohort study in Korea

Title
Effects of traffic-related air pollution on susceptibility to infantile bronchiolitis and childhood asthma: A cohort study in Korea
Authors
Lee, Ji-YoungLeem, Jong-HanKim, Hwan-CheolLamichhane, Dirga KumarHwang, Seung-SikKim, Jeong-HeePark, Myung-SookJung, Dal-YoungKo, Jung-KeunKwon, Ho-JangHong, Soo-Jong
Ewha Authors
이지영
SCOPUS Author ID
이지영scopus
Issue Date
2018
Journal Title
JOURNAL OF ASTHMA
ISSN
0277-0903JCR Link1532-4303JCR Link
Citation
vol. 55, no. 3, pp. 223 - 230
Keywords
Traffic-related air pollutionbronchiolitischildhood asthmachildrencohort
Publisher
TAYLOR & FRANCIS LTD
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Objective: This study examined the role of exposure to traffic-related air pollution (TRAP) on susceptibility to asthma in children with past episodes of bronchiolitis. Methods: The baseline data included 2,627 school children aged 6-14 years who had participated in the longitudinal follow-up survey of the Children's Health and Environmental Research of Korea. Lifetime wheezing, past episodes of bronchiolitis, and doctor-diagnosed asthma were evaluated using an International Study of Asthma and Allergies in Childhood questionnaire. We used generalized linear regression with binomial distribution to calculate the relative risk (RR) between TRAP, assessed by proximity to a main road and the total length of roads, and asthma. Results: Compared with the subjects who had less than 100 m of road length within 200-m radius from their home, those with more than 500 m of road length had significantly increased odds for infantile bronchiolitis (adjusted OR [aOR]: 1.57, 95% confidence interval [CI]: 1.01-2.42). Positive exposure-response relationships were found between residential proximity to the main road and asthma (aOR: 1.79, 95% CI: 1.05-3.06; < 75 m vs. > 700 m from a main road, P for the trend = 0.02). Closer residential proximity to the main road (< 75 m) and bronchiolitis combined increased the risks of newly diagnosed asthma (adjusted RR: 3.62, 95% CI: 1.07-12.26) compared with those without bronchiolitis and living >= 75 m away from the main road. Conclusions: TRAP appeared to be associated with an increased asthma among children with bronchiolitis, indicating the importance of modifying effects of bronchiolitis in asthma pathogenesis.
DOI
10.1080/02770903.2017.1313270
Appears in Collections:
연구기관 > 의과학연구소 > Journal papers
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