Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정성철 | * |
dc.contributor.author | 조인호 | * |
dc.contributor.author | 박윤신 | * |
dc.date.accessioned | 2018-04-25T08:13:21Z | - |
dc.date.available | 2018-04-25T08:13:21Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 1932-6254 | * |
dc.identifier.issn | 1932-7005 | * |
dc.identifier.other | OAK-22190 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242463 | - |
dc.description.abstract | Biomimetic parathyroid regeneration with sustained release of parathyroid hormone (PTH) into the blood stream is a considerable challenge in hypoparathyroidism treatment. We recently reported that tonsil-derived mesenchymal stem cells (TMSCs), if these cells were both differentiated in vitro before implantation and incorporated into a scaffold Matrigel, are a good cell source for parathyroid regeneration in a parathyroidectomized (PTX) animal model. Here, we present a new strategy for improved clinical application that enhances the sustained release of PTH by controlling mechanical stiffness using in situ-forming gelatin-hydroxyphenyl propionic acid (GH) hydrogels (GHH). Differentiated TMSCs (dTMSCs) embedded in a GHH with a strength of 4.4kPa exhibited the best sustained release of PTH and were the most effective in hypoparathyroidism treatment, showing improved blood calcium homeostasis compared with Matrigel-embedded dTMSCs. Interestingly, undifferentiated control TMSCs (cTMSCs) also released PTH in a sustained manner if incorporated into GHH. Collectively, these findings may establish a new paradigm for parathyroid regeneration that could ultimately evolve into an improved clinical application. Copyright (c) 2017 John Wiley & Sons, Ltd. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | parathyroid hormone | * |
dc.subject | gelatin hydrogels | * |
dc.subject | tonsil-derived mesenchymal stem cells | * |
dc.subject | ionized calcium | * |
dc.subject | hypoparathyroidism | * |
dc.subject | parathyroidectomized animal | * |
dc.title | Sustained release of parathyroid hormone via in situ cross-linking gelatin hydrogels improves the therapeutic potential of tonsil-derived mesenchymal stem cells for hypoparathyroidism | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 12 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | E1747 | * |
dc.relation.lastpage | E1756 | * |
dc.relation.journaltitle | JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | * |
dc.identifier.doi | 10.1002/term.2430 | * |
dc.identifier.wosid | WOS:000427137100040 | * |
dc.identifier.scopusid | 2-s2.0-85021309362 | * |
dc.author.google | Park, Yoon Shin | * |
dc.author.google | Lee, Yunki | * |
dc.author.google | Jin, Yoon Mi | * |
dc.author.google | Kim, Gyungah | * |
dc.author.google | Jung, Sung Chul | * |
dc.author.google | Park, Yoon Jeong | * |
dc.author.google | Park, Ki Dong | * |
dc.author.google | Jo, Inho | * |
dc.contributor.scopusid | 정성철(57008539100) | * |
dc.contributor.scopusid | 조인호(26643129000;56663841900) | * |
dc.contributor.scopusid | 박윤신(35975370400) | * |
dc.date.modifydate | 20240422114306 | * |