Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2018-04-25T08:13:20Z | - |
dc.date.available | 2018-04-25T08:13:20Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0022-4790 | * |
dc.identifier.issn | 1096-9098 | * |
dc.identifier.other | OAK-22194 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/242460 | - |
dc.description.abstract | BackgroundsPerioperative CA19-9 value in pancreato-biliary cancers has been recognized as a prognostic factor. Herein, we investigated survival differences and recurrence patterns after adjuvant chemoradiotherapy by perioperative CA19-9 change in surgically resected extrahepatic cholangiocarcinoma. MethodsPatients were divided into those with preoperative normal CA19-9 (Group 1, n=52), those with high preoperative and normalized postoperative CA19-9 (Group 2, n=80), and those with both high pre- and postoperative CA19-9 (Group 3, n=21). ResultsDepending on the group defined above, the 5-year overall survival (OS) (59.6%, 38.7%, and 9.5%, P<0.001) and disease-free survival (55.8%, 31.2%, and 9.5%, P<0.001) between the three groups differed. On multivariable analysis in patients other than group 1, poor prognosticators for OS were high postoperative CA19-9 (HR 2.26, P=0.008) and N1 disease (HR 2.33, P=0.001). Group 3, compared with group 2, showed higher distant metastasis rate, shorter disease-free interval, and higher CA19-9 at the time of recurrence. ConclusionsSurvival and recurrence patterns after adjuvant chemoradiotherapy are significantly affected by perioperative CA19-9 change. This may have important implications in patient selection for adjuvant chemoradiotherapy and clinical trial design. | * |
dc.language | English | * |
dc.publisher | WILEY | * |
dc.subject | adjuvant chemoradiotherapy | * |
dc.subject | CA19-9 | * |
dc.subject | extrahepatic cholangiocarcinoma | * |
dc.title | The impact of perioperative CA19-9 change on the survival and recurrence patterns after adjuvant chemoradiotherapy in resectable extrahepatic cholangiocarcinoma | * |
dc.type | Article | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 117 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 380 | * |
dc.relation.lastpage | 388 | * |
dc.relation.journaltitle | JOURNAL OF SURGICAL ONCOLOGY | * |
dc.identifier.doi | 10.1002/jso.24856 | * |
dc.identifier.wosid | WOS:000427584100006 | * |
dc.identifier.scopusid | 2-s2.0-85030323408 | * |
dc.author.google | Kim, Byoung Hyuck | * |
dc.author.google | Kim, Eunji | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Jang, Jin-Young | * |
dc.author.google | Kim, Sun Whe | * |
dc.author.google | Oh, Do-Youn | * |
dc.author.google | Chie, Eui Kyu | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |