Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 임경민 | * |
dc.date.accessioned | 2018-03-13T16:30:33Z | - |
dc.date.available | 2018-03-13T16:30:33Z | - |
dc.date.issued | 2018 | * |
dc.identifier.issn | 0887-2333 | * |
dc.identifier.other | OAK-21443 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/241255 | - |
dc.description.abstract | Ionic liquids have gained increasing attention in the chemical industry as potential green substitutes for traditional solvents. However, little is known about toxicity of ionic liquids on the skin, a major exposure portal to toxic substances. Here, we evaluated dermal toxicity of ionic liquids using human keratinocyte and fibroblast cell line, 3D reconstructed human epidermis, and full-thickness model to investigate underlying mechanisms. Cytotoxicity of ionic liquids was evaluated for representative anions, [TFSI], [PF6], [BF4], and [DCA], as well as for cations, [EMIM], [BMPY], [TBA] and [Zn], in human keratinocyte cell line, HaCaT, and human dermal fibroblasts. In our results, significant cytotoxicity was induced by ionic liquids with [TFSI] in both cell lines. Notably, cytotoxicity of [TFSI] containing ionic liquids was comparable to xylene, a toxic conventional organic solvent. Fluorescent and flow cytometric analysis revealed that [TFSI]-exposed cells underwent necrotic cell death. Reactive oxygen species (ROS) was increased while the amount of glutathione was decreased by [TFSI] in dose-dependent manner, which was reversed by antioxidant, N-acetyleysteine. In 3D reconstructed human epidermis and full-thickness model, a single application of [TFSI] induced toxicity although it was minimal and largely limited to epidermal layer. Collectively, these results demonstrated potential dermal toxicity of ionic liquids. | * |
dc.language | English | * |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | * |
dc.subject | Ionic liquid | * |
dc.subject | Bis(trifluoromethanesulfonyl)imide, TFSI | * |
dc.subject | Dermal toxicity | * |
dc.subject | ROS | * |
dc.subject | 3D skin model | * |
dc.title | Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models | * |
dc.type | Article | * |
dc.relation.volume | 46 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 194 | * |
dc.relation.lastpage | 202 | * |
dc.relation.journaltitle | TOXICOLOGY IN VITRO | * |
dc.identifier.doi | 10.1016/j.tiv.2017.09.025 | * |
dc.identifier.wosid | WOS:000422811300023 | * |
dc.identifier.scopusid | 2-s2.0-85031099821 | * |
dc.author.google | Hwang, Jee-hyun | * |
dc.author.google | Park, Hyeonji | * |
dc.author.google | Choi, Dal Woong | * |
dc.author.google | Nam, Ki Taek | * |
dc.author.google | Lim, Kyung-Min | * |
dc.contributor.scopusid | 임경민(8916551700) | * |
dc.date.modifydate | 20240220115649 | * |