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Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma

Title
Clinicopathological Characteristics of Hyperdiploidy with High-Risk Cytogenetics in Multiple Myeloma
Authors
Yang, NaeryMun, Yeung ChulSeong, Chu-MyongHuh, Hee JinHuh, Jungwon
Ewha Authors
허정원
SCOPUS Author ID
허정원scopus
Issue Date
2018
Journal Title
ANNALS OF LABORATORY MEDICINE
ISSN
2234-3806JCR Link2234-3814JCR Link
Citation
vol. 38, no. 2, pp. 160 - +
Keywords
HyperdiploidyMultiple myelomaCytogeneticsHigh risk
Publisher
KOREAN SOC LABORATORY MEDICINE
Indexed
SCIE; SCOPUS; KCI WOS
Abstract
In multiple myeloma (MM), hyperdiploidy (HD) is known to impart longer overall survival. However, it is unclear whether coexistent HD ameliorates the adverse effects of known high-risk cytogenetics in MM patients. To address this issue, we investigated the clinicopathological characteristics of HD with high-risk cytogenetics in MM. Ninety-seven patients with MM were included in the study. For metaphase cytogenetics (MC), unstimulated cells from bone marrow aspirates were cultured for either 24 or 48 hours. To detect HD by interphase fluorescence in situ hybridization (iFISH), we assessed trisomies of chromosomes 5, 7, 9, 11, 15, and 17. Of the 97 MM patients, 40 showed HD. The frequency of co-occurrence of HD and high-risk cytogenetics was 14% (14/97). When the clinicopathological characteristics were compared between the two groups of HD with high-risk cytogenetics vs. non-HD (NHD) with high-risk cytogenetics, the level of beta 2 microglobulin and stage distribution significantly differed (P=0.020, P=0.032, respectively). This study shows that some of the clinicopathological characteristics of MM patients with high-risk cytogenetics differ according to HD or NHD status.
DOI
10.3343/alm.2018.38.2.160
Appears in Collections:
의과대학 > 의학과 > Journal papers
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