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Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD

Title
Urinary desmosine is associated with emphysema severity and frequent exacerbation in patients with COPD
Authors
Kim, ChanghwanKo, YousangKim, Su HeeYoo, Hyun JuLee, Jae SeungRhee, Chin KookLee, Jin HwaLee, Ji-HyunKim, Tae-HyungLim, Seong YongYoo, Kwang HaSeo, Joon BeomOh, Yeon-MokLee, Sang-DoPark, Yong Bum
Ewha Authors
이진화
SCOPUS Author ID
이진화scopus
Issue Date
2018
Journal Title
RESPIROLOGY
ISSN
1323-7799JCR Link1440-1843JCR Link
Citation
vol. 23, no. 2, pp. 176 - 181
Keywords
chronic obstructive pulmonary diseaseemphysemamass spectrometryurinary desmosines
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Abstract
Background and objectiveMatrix degradation is a key feature of chronic obstructive pulmonary disease (COPD). Desmosine and isodesmosine (desmosines) are excreted in urine following matrix degradation. The main purpose of this study was to investigate the association between computed tomography (CT) emphysema indices and urinary desmosines in patients with COPD. MethodsA total of 152 subjects were selected from the Korean Obstructive Lung Disease cohort. Their urine samples were assayed for desmosines using liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods. The cohort was divided into emphysema-dominant (n=80) and non-emphysema dominant- (n=72) groups according to the CT emphysema index. ResultsThe level of urinary desmosines was significantly higher in the emphysema-dominant group. Significant differences were also observed between the two groups for body mass index and lung function. Multivariate analysis indicated that a high level of urinary desmosines was a significant independent predictor of emphysema (relative risk: 2.6; 95% CI: 1.11-6.09; P=0.028). The percentage of frequent exacerbators was significantly higher in the high urinary desmosine group in the first year of follow-up (P=0.041). The mean number of exacerbations was higher in the high urinary desmosine group, although this difference was not statistically significant (P=0.067). The changes in emphysema index did not differ between the two urinary desmosine groups over 3years of follow-up. ConclusionThis study indicates that the level of urinary desmosines measured by LC-MS/MS methods is associated with the CT emphysema index. Urinary desmosine can be a useful predictor in identifying frequent exacerbators. Previous studies have revealed inconsistencies as to the association between emphysema severity and desmosines released due to matrix degradation in chronic obstructive pulmonary disease (COPD). This study suggests that urinary desmosines, measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, are useful for predicting emphysema severity and frequent exacerbation in patients with COPD.
DOI
10.1111/resp.13170
Appears in Collections:
의과대학 > 의학과 > Journal papers
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