Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 강소라 | - |
dc.date.accessioned | 2018-03-13T16:30:20Z | - |
dc.date.available | 2018-03-13T16:30:20Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1742-4801 | - |
dc.identifier.other | OAK-22016 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/241189 | - |
dc.description.abstract | Various types of skin substitutes composed of fibroblasts and/or keratinocytes have been used for the treatment of diabetic ulcers. However, the effects have generally not been very dramatic. Recently, human umbilical cord blood-derived mesenchymal stromal cells (hUCB-MSCs) have been commercialised for cartilage repair as a first cell therapy product using allogeneic stem cells. In a previous pilot study, we reported that hUCB-MSCs have a superior wound-healing capability compared with fibroblasts. The present study was designed to compare the treatment effect of hUCB-MSCs with that of fibroblasts on the diabetic wound healing in vitro. Diabetic fibroblasts were cocultured with healthy fibroblasts or hUCB-MSCs. Five groups were evaluated: group I, diabetic fibroblasts without coculture; groups II and III, diabetic fibroblasts cocultured with healthy fibroblasts or hUCB-MSCs; and groups IV and V, no cell cocultured with healthy fibroblasts or hUCB-MSCs. After a 3-day incubation, cell proliferation, collagen synthesis levels and glycosaminoglycan levels, which are the major contributing factors in wound healing, were measured. As a result, a hUCB-MSC-treated group showed higher cell proliferation, collagen synthesis and glycosaminoglycan level than a fibroblast-treated group. In particular, there were significant statistical differences in collagen synthesis and glycosaminoglycan levels (P = 0·029 and P = 0·019, respectively). In conclusion, these results demonstrate that hUCB-MSCs may have a superior effect to fibroblasts in stimulating diabetic wound healing. © 2017 Medicalhelplines.com Inc and John Wiley & Sons Ltd | - |
dc.language | English | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.subject | diabetic wound healing | - |
dc.subject | fibroblast | - |
dc.subject | human umbilical cord blood stromal cells | - |
dc.title | Comparison of human umbilical cord blood-derived mesenchymal stem cells with healthy fibroblasts on wound-healing activity of diabetic fibroblasts | - |
dc.type | Article | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 15 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 133 | - |
dc.relation.lastpage | 139 | - |
dc.relation.journaltitle | International Wound Journal | - |
dc.identifier.doi | 10.1111/iwj.12849 | - |
dc.identifier.wosid | WOS:000423818800018 | - |
dc.identifier.scopusid | 2-s2.0-85041301926 | - |
dc.author.google | Jung J.-A. | - |
dc.author.google | Yoon Y.-D. | - |
dc.author.google | Lee H.-W. | - |
dc.author.google | Kang S.-R. | - |
dc.author.google | Han S.-K. | - |
dc.contributor.scopusid | 강소라(55572968300) | - |
dc.date.modifydate | 20210611163848 | - |