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Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy

Title
Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy
Authors
Li X.Yu S.Lee D.Kim G.Lee B.Cho Y.Zheng B.-Y.Ke M.-R.Huang J.-D.Nam K.T.Chen X.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2018
Journal Title
ACS Nano
ISSN
1936-0851JCR Link
Citation
ACS Nano vol. 12, no. 1, pp. 681 - 688
Keywords
activatablenanotheranosticsnucleic-acid-responsive disassemblyphotodynamic therapysupramolecular assembly
Publisher
American Chemical Society
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission and singlet oxygen generation associated with the formation of free PcS, mild photothermal heating, and a concomitant chemotherapeutic effect associated with the formation of free MA. In vivo evaluations indicate that PcS-MA nanostructures have a high level of accumulation in tumor tissues, are capable of being used for cancer imaging, and have significantly improved anticancer effect compared to that of PcS. This study demonstrates an attractive strategy for overcoming the limitations of photodynamic cancer therapy. © 2017 American Chemical Society.
DOI
10.1021/acsnano.7b07809
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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