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dc.contributor.author하은희-
dc.contributor.author박혜숙-
dc.date.accessioned2018-02-08T16:32:11Z-
dc.date.available2018-02-08T16:32:11Z-
dc.date.issued2017-
dc.identifier.issn0048-9697-
dc.identifier.issn1879-1026-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/239874-
dc.description.abstractBackground: Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. Methods: We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3 years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5 years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of >= 60 or < 60 were used as outcomes. Results: The geometric mean of mercury concentrations in cord blood was 5.52 mu g/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (beta= 1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (beta = 2.24, 95% CI: 0.22, 4.27), and at 2 years (beta = 2.12, 95% CI: 0.54, 3.70) and 3 years (beta = 2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR] = 1.31, 95% CI: 1.08, 1.60) and in cord blood (RR = 1.28, 95% CI: 1.01, 1.63). Conclusion: We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5 years of age. Further study on the long-term effects of mercury exposure is recommended. (C) 2017 Elsevier B.V. All rights reserved.-
dc.languageEnglish-
dc.publisherELSEVIER SCIENCE BV-
dc.subjectAutistic behavior-
dc.subjectBirth cohort-
dc.subjectBlood mercury-
dc.subjectEarly childhood exposure-
dc.subjectPrenatal exposure-
dc.titleAssociations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: The Mothers and Children's Environmental Health (MOCEH) study-
dc.typeArticle-
dc.relation.volume605-
dc.relation.indexSCI-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.startpage251-
dc.relation.lastpage257-
dc.relation.journaltitleSCIENCE OF THE TOTAL ENVIRONMENT-
dc.identifier.doi10.1016/j.scitotenv.2017.06.227-
dc.identifier.wosidWOS:000408275500028-
dc.identifier.scopusid2-s2.0-85021405347-
dc.author.googleRyu, Jia-
dc.author.googleHa, Eun-Hee-
dc.author.googleKimb, Boong-Nyun-
dc.author.googleHa, Mina-
dc.author.googleKim, Yangho-
dc.author.googlePark, Hyesook-
dc.author.googleHong, Yun-Chul-
dc.author.googleKim, Kyoung-Nam-
dc.contributor.scopusid하은희(7003615774)-
dc.contributor.scopusid박혜숙(55713710200)-
dc.date.modifydate20180329110124-
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의과대학 > 의학과 > Journal papers
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