Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 하은희 | * |
dc.contributor.author | 박혜숙 | * |
dc.date.accessioned | 2018-02-08T16:32:11Z | - |
dc.date.available | 2018-02-08T16:32:11Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0048-9697 | * |
dc.identifier.issn | 1879-1026 | * |
dc.identifier.other | OAK-20962 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239874 | - |
dc.description.abstract | Background: Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. Methods: We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3 years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5 years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of >= 60 or < 60 were used as outcomes. Results: The geometric mean of mercury concentrations in cord blood was 5.52 mu g/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (beta= 1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (beta = 2.24, 95% CI: 0.22, 4.27), and at 2 years (beta = 2.12, 95% CI: 0.54, 3.70) and 3 years (beta = 2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR] = 1.31, 95% CI: 1.08, 1.60) and in cord blood (RR = 1.28, 95% CI: 1.01, 1.63). Conclusion: We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5 years of age. Further study on the long-term effects of mercury exposure is recommended. (C) 2017 Elsevier B.V. All rights reserved. | * |
dc.language | English | * |
dc.publisher | ELSEVIER SCIENCE BV | * |
dc.subject | Autistic behavior | * |
dc.subject | Birth cohort | * |
dc.subject | Blood mercury | * |
dc.subject | Early childhood exposure | * |
dc.subject | Prenatal exposure | * |
dc.title | Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: The Mothers and Children's Environmental Health (MOCEH) study | * |
dc.type | Article | * |
dc.relation.volume | 605 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 251 | * |
dc.relation.lastpage | 257 | * |
dc.relation.journaltitle | SCIENCE OF THE TOTAL ENVIRONMENT | * |
dc.identifier.doi | 10.1016/j.scitotenv.2017.06.227 | * |
dc.identifier.wosid | WOS:000408275500028 | * |
dc.identifier.scopusid | 2-s2.0-85021405347 | * |
dc.author.google | Ryu, Jia | * |
dc.author.google | Ha, Eun-Hee | * |
dc.author.google | Kimb, Boong-Nyun | * |
dc.author.google | Ha, Mina | * |
dc.author.google | Kim, Yangho | * |
dc.author.google | Park, Hyesook | * |
dc.author.google | Hong, Yun-Chul | * |
dc.author.google | Kim, Kyoung-Nam | * |
dc.contributor.scopusid | 하은희(7003615774) | * |
dc.contributor.scopusid | 박혜숙(57201862679;56148186100) | * |
dc.date.modifydate | 20240419135248 | * |