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|dc.description.abstract||Background: Although mercury is an established neurotoxin, only few longitudinal studies have investigated the association between prenatal and early childhood mercury exposure and autistic behaviors. Methods: We conducted a longitudinal cohort study using an ongoing prospective birth cohort initiated in 2006, wherein blood mercury levels were measured at early and late pregnancy; in cord blood; and at 2 and 3 years of age. We analyzed 458 mother-child pairs. Autistic behaviors were assessed using the Social Responsiveness Scale (SRS) at 5 years of age. Both continuous SRS T-scores and T-scores dichotomized by a score of >= 60 or < 60 were used as outcomes. Results: The geometric mean of mercury concentrations in cord blood was 5.52 mu g/L. In adjusted models, a doubling of blood mercury levels at late pregnancy (beta= 1.84, 95% confidence interval [CI]: 0.39, 3.29), in cord blood (beta = 2.24, 95% CI: 0.22, 4.27), and at 2 years (beta = 2.12, 95% CI: 0.54, 3.70) and 3 years (beta = 2.80, 95% CI: 0.89, 4.72) of age was positively associated with the SRS T-scores. When the SRS T-scores were dichotomized, we observed positive associations with mercury levels at late pregnancy (relative risk [RR] = 1.31, 95% CI: 1.08, 1.60) and in cord blood (RR = 1.28, 95% CI: 1.01, 1.63). Conclusion: We found that blood mercury levels at late pregnancy and early childhood were associated with more autistic behaviors in children at 5 years of age. Further study on the long-term effects of mercury exposure is recommended. (C) 2017 Elsevier B.V. All rights reserved.||-|
|dc.publisher||ELSEVIER SCIENCE BV||-|
|dc.subject||Early childhood exposure||-|
|dc.title||Associations of prenatal and early childhood mercury exposure with autistic behaviors at 5 years of age: The Mothers and Children's Environmental Health (MOCEH) study||-|
|dc.relation.journaltitle||SCIENCE OF THE TOTAL ENVIRONMENT||-|
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