View : 3 Download: 0

Stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood: Mothers' and Children's Environmental Health (MOCEH) birth cohort study

Title
Stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood: Mothers' and Children's Environmental Health (MOCEH) birth cohort study
Authors
Kim, Ja HyeongJeong, Kyoung SookKim, YanghoLee, HyungminPark, HyewonHa, EunheeHong, Yun-ChulHa, MinaPark, HyesookKim, Bung-NyunLee, Soo-JeongLee, Kyung Yeon
Ewha Authors
하은희박혜숙
SCOPUS Author ID
하은희scopus; 박혜숙scopus
Issue Date
2017
Journal Title
SCIENCE OF THE TOTAL ENVIRONMENT
ISSN
0048-9697JCR Link1879-1026JCR Link
Citation
vol. 609, pp. 153 - 159
Keywords
StabilityLeadMercuryCadmiumCord bloodChildIntelligence
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
The objective of this study was to investigate stability of cognitive development during the first five years of life in relation to heavy metal concentrations in umbilical cord blood in Korean children. This research is parr of the Mothers' and Children's Environmental Health (MOCEH) study, a multi-center prospective birth cohort study of pregnant women in Korea who were recruited from 2006 to 2010. We analyzed the complete follow-up data of children who were 5 years-old in 2016. We measured lead, mercury, and cadmium levels in the umbilical cord blood of 251 children, and analyzed them, for whom neuroclevelopmental data were available. We determined stability of cognitive development scores using three methods. First, we used partial correlation analyses to examine the stability of cognitive development at each measurement time. Second, we used Cramer's V to investigate the magnitude and direction of changes in cognitive development scores at each follow-up period among three groups (high, medium, and low scores). The results showed that cognitive development scores measured at the closest times had the strongest correlations, and the stability of cognitive development scores increased with age, from 6 to 60 months. Groups at the extreme ends of cognitive development (high or low scores) had more stable scores, and this tendency was also stronger in infants-24 months-old. The stability of cognitive development was unrelated to the umbilical cord level of heavy metals, based on analysis with Fisher's transformation. In conclusion, the present study showed that the cognitive development scores in a cohort of infants (6 to 60 months-old) were stable. (C) 2017 Elsevier B.V. All rights reserved.
DOI
10.1016/j.scitotenv.2017.07.074
Appears in Collections:
의학전문대학원 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE