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Prenatal mercury exposure, fish intake and neurocognitive development during first three years of life: Prospective cohort mothers and Children's environmental health (MOCEH) study

Title
Prenatal mercury exposure, fish intake and neurocognitive development during first three years of life: Prospective cohort mothers and Children's environmental health (MOCEH) study
Authors
Kim, YeniHa, Eun-HeePark, HyesookHa, MinaKim, YanghoHong, Yun-ChulLee, Eun JungKim, HyesookChang, NamsooKim, Bung-Nyun
Ewha Authors
장남수박혜숙김혜숙
SCOPUS Author ID
장남수scopus; 박혜숙scopus; 김혜숙scopus
Issue Date
2018
Journal Title
SCIENCE OF THE TOTAL ENVIRONMENT
ISSN
0048-9697JCR Link1879-1026JCR Link
Citation
vol. 615, pp. 1192 - 1198
Keywords
BayleyFishHgNeurodevelopmentPrenatalPUFA
Publisher
ELSEVIER SCIENCE BV
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Objectives: In this prospective cohort study, the effects of prenatal Hg exposure on neurocognitive development during the first 3 years of life were investigated. Methods: The maternal blood levels of Hg were assessed during pregnancy and in cord blood. Maternal fish intake was assessed by interviewing the weekly frequency of fish intake during pregnancy. Maternal n-3 and n-6 fatty acid intake was estimated based on 24 h recall food intake interview. The mental (MDI) and psychomotor (PDI) development index scores were assessed using the Bayley Scales of Infant Development at 6, 12, 24, 36 months of age. Results: The geometric mean of the maternal blood Hg concentration was 3.3 mu g/L (10th percentile = 1.81; 90th = 5.91) during the early pregnancy, 3.0 mu g/L (10th = 1.68; 90th = 5.57) during late pregnancy, and 5.1 mu g/L (10th = 2.94; 90th = 8.93) in cord blood. After adjusting for weekly frequency of fish intake, the blood Hg concentrations during early pregnancy showed association with the adjusted MDI (beta = -0.408, p = 0.048) and PDI scores (beta = -0.550, p = 0.031) at 6 months. After further adjusting for n-3 and n-6 fatty acids estimated based on 24 h recall of food intake, the blood Hg concentrations during early pregnancy showed association with the MDI (beta = -0.489, p = 0.026) and PDI (beta = -0.664, p = 0.015) at 6 months. Conclusion: These results show that prenatal Hg exposure during early pregnancy adversely associated with early neurodevelopment during infancy, after adjusting for fish and n-3, n-6 fatty acid intake. Consuming fish high in fatty acids and low in Hg during early pregnancy may be important to neurocognitive development at early infancy. (C) 2017 Published by Elsevier B.V.
DOI
10.1016/j.scitotenv.2017.10.014
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신산업융합대학 > 식품영양학과 > Journal papers
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