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Does tranexamic acid increase the risk of thromboembolism after bilateral simultaneous total knee arthroplasties in Asian Population?

Title
Does tranexamic acid increase the risk of thromboembolism after bilateral simultaneous total knee arthroplasties in Asian Population?
Authors
Kim, Young-HooPark, Jang-WonKim, Jun-ShikSeo, Dong-Hyuk
Ewha Authors
김영후김준식박장원
SCOPUS Author ID
김영후scopus; 김준식scopus; 박장원scopus
Issue Date
2018
Journal Title
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
ISSN
0936-8051JCR Link1434-3916JCR Link
Citation
vol. 138, no. 1, pp. 83 - 89
Keywords
Tranexamic acidRisk of thromboembolismSimultaneous bilateral total knee arthroplastyAmount of blood lossAmount of transfusionAsian population
Publisher
SPRINGER
Indexed
SCIE; SCOPUS WOS scopus
Abstract
To ascertain whether tranexamic acid reduces the blood loss and transfusion rate and volumes; increase the prevalence of deep vein thrombosis (DVT); and investigate factors associated with DVT in patients undergoing primary bilateral total knee arthroplasties (TKAs) without use of chemical thromboprophylaxis. There were 874 patients (1748 knees) in the control group who did not receive tranexamic acid and 871 patients (1742 knees) in the study group who received tranexamic acid. Mechanical compression device was applied without any chemical thromboprophylaxis. Transfusion rates and volumes were recorded. DVT was diagnosed using both sonogram and venogram at 7 or 8 day post-operatively. Intra- and post-operative blood loss and transfusion volumes were significantly lower in the tranexamic acid group. The prevalence of DVT was 14% (245 of 1748 knees) in the control group and 18% (314 of 1742 knees) in the tranexamic acid group. Pre- and post-operative perfusion lung scans revealed no evidence of PE in any patients in either group. Coagulation or thrombophilic data or molecular genetic testing was not significantly different between the two groups. The use of tranexamic acid reduces the volume of blood transfusion and does not increase the prevalence of DVT or PE in the patients who did not receive routine chemical thromboprophylaxis after primary bilateral simultaneous sequential TKAs in Asian patients.
DOI
10.1007/s00402-017-2791-y
Appears in Collections:
의과대학 > 의학과 > Journal papers
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