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Clinical implications of the plasma EphA2 receptor level in critically ill patients with septic shock

Title
Clinical implications of the plasma EphA2 receptor level in critically ill patients with septic shock
Authors
Lee, Su HwanShin, Ju HyeSong, Joo HanLeem, Ah YoungPark, Moo SukKim, Young SamChang, JoonChung, Kyung Soo
Ewha Authors
이수환
Issue Date
2017
Journal Title
SCIENTIFIC REPORTS
ISSN
2045-2322JCR Link
Citation
vol. 7
Publisher
NATURE PUBLISHING GROUP
Indexed
SCOPUS; SCI; SCIE WOS scopus
Abstract
The Eph/ephrin receptor ligand system is known to play a role in inflammation induced by infection, injury, and inflammatory diseases. The present study aimed to evaluate plasma EphA2 receptor levels in critically ill patients with sepsis. This study was a prospective cohort study evaluating samples and clinical data from the medical intensive care unit (MICU) of a 2000-bed university tertiary referral hospital in South Korea. Positive correlations of the plasma EphA2 receptor level with the acute physiology and chronic health evaluation (APACHE) II score and the sequential organ failure assessment (SOFA) score were observed. The area under the curve (AUC) for the plasma EphA2 receptor level on a receiver operating characteristic curve was 0.690 (95% confidence interval [CI], 0.608-0.764); the AUCs for the APACHE II score and SOFA scores were 0.659 (95% CI, 0.576-0.736) and 0.745 (95% CI, 0.6660.814), respectively. A Cox proportional hazard model identified an association between an increased plasma EphA2 receptor level (>51.5 pg mL(-1)) and increased risk of 28-day mortality in the MICU (hazard ratio = 3.22, 95% CI, 1.709-6.049). An increased plasma EphA2 receptor level was associated with sepsis severity and 28-day mortality among sepsis patients.
DOI
10.1038/s41598-017-17909-7
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의료원 > 의료원 > Journal papers
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