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Effects of Concomitant Medication Use on Gefitinib-Induced Hepatotoxicity

Title
Effects of Concomitant Medication Use on Gefitinib-Induced Hepatotoxicity
Authors
Cho, SoyeonYee, JeongKim, Jae YounRhie, Sandy JeongGwak, Hye Sun
Ewha Authors
곽혜선이정연
SCOPUS Author ID
곽혜선scopus; 이정연scopus
Issue Date
2018
Journal Title
JOURNAL OF CLINICAL PHARMACOLOGY
ISSN
0091-2700JCR Link1552-4604JCR Link
Citation
vol. 58, no. 2, pp. 263 - 268
Keywords
gefitinibhepatotoxicityH2 antagonistproton pump inhibitorEGFR mutation
Publisher
WILEY
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Gefitinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) patients. Severe hepatotoxicity was observed, but only a few cases have been reported on the hepatotoxicity of gefitinib. This study aimed to investigate the association between gefitinib-induced hepatotoxicity and various factors including concomitant medications in lung cancer patients. From January 2013 to December 2014, a retrospective study was performed with NSCLC patients who were treated with gefitinib. Associations between hepatotoxicity and various factors including concomitant drugs were analyzed. Based on multivariate models, it was found that H2 antagonists, proton pump inhibitors (PPIs), and H2 antagonists or PPIs increased hepatotoxicity by about 1.5- to 1.7-fold. Patients younger than 65 years showed 1.6 times higher hepatotoxicity than those older than 65 years. Patients with EGFR mutations had around 2-fold higher hepatotoxicity, and the percentage of incidence of hepatotoxicity because of exon 19 deletion was 32.7%. Our study showed that anti-acid-secreting agents in addition to age younger than 65 years and EGFR mutation were associated with gefitinib-induced hepatotoxicity. Thus, close monitoring of liver function is recommended, especially for patients using anti-acid-secreting agents.
DOI
10.1002/jcph.1010
Appears in Collections:
약학대학 > 약학과 > Journal papers
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