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Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen

Title
Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
Authors
Ju, Ji-MinJung, Min HoNam, GiriKim, WoojinOh, SehwaKim, Hyun DukKim, Joo YoungChang, JunLee, Sung HakPark, Gyeong SinMin, Chang-KiLee, Dong-SupKim, Moon GyoChoi, KyunghoChoi, Eun Young
Ewha Authors
장준김주영
SCOPUS Author ID
장준scopus; 김주영scopus
Issue Date
2018
Journal Title
NATURE COMMUNICATIONS
ISSN
2041-1723JCR Link
Citation
vol. 9
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS
Abstract
Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8(+) T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60(+) hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors.
DOI
10.1038/s41467-017-02665-z
Appears in Collections:
약학대학 > 약학과 > Journal papers
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