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Heat Shock Protein-Inducing Property of Diarylheptanoid Containing Chalcone Moiety from Alpinia katsumadai

Title
Heat Shock Protein-Inducing Property of Diarylheptanoid Containing Chalcone Moiety from Alpinia katsumadai
Authors
Nam, Joo-WonLee, Yun-Sil
Ewha Authors
이윤실
SCOPUS Author ID
이윤실scopus
Issue Date
2017
Journal Title
MOLECULES
ISSN
1420-3049JCR Link
Citation
vol. 22, no. 10
Keywords
Alpinia katsumadaidiarylheptanoidheat shock factor (HSF)chalconeheat shock protein (HSP)
Publisher
MDPI AG
Indexed
SCIE; SCOPUS WOS scopus
Abstract
A new diarylheptanoid containing a chalcone moiety, katsumain H (1), was isolated from the seeds of Alpinia katsumadai. The structure was elucidated using a combination of 1D/2D NMR spectroscopy and mass spectrometry data analysis. The absolute configurations of C-3, C-5, and C-7 in 1 were assigned based on its optical rotation and after comparing its NMR chemical shifts with those of its diastereoisomers, katsumain E and katsumain F, which were previously isolated from this plant and characterized. In this study, the stimulatory effects of compounds 1 and 2 were evaluated on heat shock factor 1 (HSF1), heat shock protein 27 (HSP27), and HSP70. Compounds 1 and 2 increased the expression of HSF1 (1.056- and 1.200-fold, respectively), HSP27 (1.312- and 1.242-fold, respectively), and HSP70 (1.234- and 1.271-fold, respectively), without increased cytotoxicity.
DOI
10.3390/molecules22101750
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약학대학 > 약학과 > Journal papers
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