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A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease

Title
A genome-wide association analysis identifies NMNAT2 and HCP5 as susceptibility loci for Kawasaki disease
Authors
Kim, Jae-JungYun, Sin WeonYu, Jeong JinYoon, Kyung LimLee, Kyung-YilKil, Hong-RyangKim, Gi BeomHan, Myung-KiSong, Min SeobLee, Hyoung DooHa, Kee SooSohn, SejungJohnson, Todd A.Takahashi, AtsushiKubo, MichiakiTsunoda, TatsuhikoIto, KaoruOnouchi, YoshihiroHong, Young MiJang, Gi YoungLee, Jong-KeukKorean Kawasaki Dis Genetics Conso
Ewha Authors
홍영미
SCOPUS Author ID
홍영미scopus
Issue Date
2017
Journal Title
JOURNAL OF HUMAN GENETICS
ISSN
1434-5161JCR Link1435-232XJCR Link
Citation
vol. 62, no. 12, pp. 1023 - 1029
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
Kawasaki disease (KD), a systemic vasculitis of infants and children, manifests as fever and mucocutaneous inflammation. Although its etiology is largely unknown, the epidemiological data suggest that genetic factors are important in KD susceptibility. To identify genetic variants influencing KD susceptibility, we performed a genome-wide association study (GWAS) and replication study using a total of 915 children with KD and 4553 controls in the Korean population. Six single-nucleotide polymorphisms (SNPs) in three loci were associated significantly with KD susceptibility (P<1.0 x 10(-5)), including the previously reported BLK locus (rs6993775, odds ratio (OR) = 1.52, P = 2.52 x 10(-1)1). The other two loci were newly identified: NMNAT2 on chromosome 1q25.3 (rs2078087, OR = 1.33, P = 1.15 x 10(-6)) and the human leukocyte antigen (HLA) region on chromosome 6p21.3 (HLA-C, HLA-B, MICA and HCP5) (rs9380242, rs9378199, rs9266669 and rs6938467; OR= 1.33-1.51, P= 8.93 x 10(-6) to 5.24 x 10(-8)). Additionally, SNP rs17280682 in NLRP14 was associated significantly with KD with a family history (18 cases vs 4553 controls, OR= 6.76, P= 5.46 x 10(-6)). These results provide new insights into the pathogenesis and pathophysiology of KD.
DOI
10.1038/jhg.2017.87
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의과대학 > 의학과 > Journal papers
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