Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 김규보 | * |
dc.date.accessioned | 2018-01-11T16:30:29Z | - |
dc.date.available | 2018-01-11T16:30:29Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 0360-3016 | * |
dc.identifier.other | OAK-21646 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239671 | - |
dc.description.abstract | Purpose To evaluate chemoradiotherapy (CRT)-induced changes in the expression levels of programmed death-ligand 1 (PD-L1) and CD8+ tumor-infiltrating lymphocytes (TILs) and prognostic associations in rectal cancer. Methods and Materials We performed a paired analysis using pre-CRT biopsies and the corresponding post-CRT resected tissues of 123 rectal cancer patients undergoing preoperative CRT followed by surgery between 2005 and 2012. Immunohistochemistry of PD-L1 and CD8 was analyzed for the specimens. Results The expression levels of PD-L1 and density of CD8+ TILs increased after CRT (P<.001 for both). With cutoffs using each median value, sustained higher expression of PD-L1 at pre- and post-CRT (high-to-high) was associated with less increase in the density of CD8+ TILs (P=.020). Patients representing sustained high-to-high PD-L1 expression had poorer overall survival and disease-free interval on univariate Kaplan-Meier analysis (P=.018 and.029, respectively), with inferior disease-free interval in low-to-low density CD8+ TILs (P=.010). On multivariate analysis, 2 subgroups with high baseline PD-L1 expression level, the high-to-low and high-to-high alterations, showed worse overall survival (hazard ratio 8.34, 95% confidence interval 1.85-37.53 and hazard ratio 11.03, 95% confidence interval 2.33-52.29, respectively), with the highest mortality risk observed in the high-to-high group. Conclusions This study verified the CRT-induced immunologic shift toward increases in PD-L1 expression and density of CD8+ TILs in rectal cancer patients. The alteration profiles of checkpoint-related molecules identified the patients with poor prognosis, suggesting potential candidates who can benefit from combining CRT and checkpoint inhibitors. © 2017 Elsevier Inc. | * |
dc.language | English | * |
dc.publisher | Elsevier Inc. | * |
dc.title | Chemoradiation-Induced Alteration of Programmed Death-Ligand 1 and CD8+ Tumor-Infiltrating Lymphocytes Identified Patients With Poor Prognosis in Rectal Cancer: A Matched Comparison Analysis | * |
dc.type | Article | * |
dc.relation.issue | 5 | * |
dc.relation.volume | 99 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1216 | * |
dc.relation.lastpage | 1224 | * |
dc.relation.journaltitle | International Journal of Radiation Oncology Biology Physics | * |
dc.identifier.doi | 10.1016/j.ijrobp.2017.07.004 | * |
dc.identifier.wosid | WOS:000416919400030 | * |
dc.identifier.scopusid | 2-s2.0-85034955526 | * |
dc.author.google | Lim Y.J. | * |
dc.author.google | Koh J. | * |
dc.author.google | Kim S. | * |
dc.author.google | Jeon S.-R. | * |
dc.author.google | Chie E.K. | * |
dc.author.google | Kim K. | * |
dc.author.google | Kang G.H. | * |
dc.author.google | Han S.-W. | * |
dc.author.google | Kim T.-Y. | * |
dc.author.google | Jeong S.-Y. | * |
dc.author.google | Park K.J. | * |
dc.author.google | Wu H.-G. | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.date.modifydate | 20240222162403 | * |