View : 3 Download: 0

Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice

Title
Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice
Authors
Park, SeonyoungLee, Mak-SoonJung, SunyoonLee, SeohyunKwon, OranKreuter, Matthias HeinrichPerrinjaquet-Moccetti, TaniaMin, BokkeeYun, Seong HoKim, Yangha
Ewha Authors
김양하권오란
SCOPUS Author ID
김양하scopus; 권오란scopus
Issue Date
2017
Journal Title
JOURNAL OF MEDICINAL FOOD
ISSN
1096-620XJCR Link1557-7600JCR Link
Keywords
cytokinesEchinacea purpureaimmuneNK cellrestraint stressT lymphocyte
Publisher
MARY ANN LIEBERT, INC
Indexed
SCI; SCIE; SCOPUS; KCI WOS
Abstract
Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA((R))894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P<.05). Echinacea treatment significantly increased the percentages of CD4+ and CD8+ T lymphocytes in the blood (P<.05). In addition, Echinacea restored serum cytokine levels, including interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-17 (IL-17), as well as the mRNA expressions of these cytokines in spleen (P<.05). Our findings suggest that Echinacea might have beneficial effects on restraint stress-induced immunosuppression by increasing splenocyte proliferation and NK cell activity, while modulating T lymphocyte subsets and cytokine levels in the blood.
DOI
10.1089/jmf.2017.4073
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE