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Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice
- Echinacea purpurea Protects Against Restraint Stress-Induced Immunosuppression in BALB/c Mice
- Park, Seonyoung; Lee, Mak-Soon; Jung, Sunyoon; Lee, Seohyun; Kwon, Oran; Kreuter, Matthias Heinrich; Perrinjaquet-Moccetti, Tania; Min, Bokkee; Yun, Seong Ho; Kim, Yangha
- Ewha Authors
- 김양하; 권오란
- SCOPUS Author ID
- 김양하; 권오란
- Issue Date
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- 1096-620X; 1557-7600
- cytokines; Echinacea purpurea; immune; NK cell; restraint stress; T lymphocyte
- MARY ANN LIEBERT, INC
- SCI; SCIE; SCOPUS; KCI
- Echinacea purpurea has been widely used for the prevention and treatment of upper respiratory tract infections and the common cold. The restraint stress has been reported to suppress a broad spectrum of immune functions. The aim of this study was to investigate the protective effects of the pressed juice of E. purpurea (L.) Moench (EFLA((R))894; Echinacea) against restraint stress-induced immunosuppression in BALB/c mice. Echinacea significantly normalized the restraint stress-induced reduction in splenocyte proliferation and splenic natural killer (NK) cell activity (P<.05). Echinacea treatment significantly increased the percentages of CD4+ and CD8+ T lymphocytes in the blood (P<.05). In addition, Echinacea restored serum cytokine levels, including interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-17 (IL-17), as well as the mRNA expressions of these cytokines in spleen (P<.05). Our findings suggest that Echinacea might have beneficial effects on restraint stress-induced immunosuppression by increasing splenocyte proliferation and NK cell activity, while modulating T lymphocyte subsets and cytokine levels in the blood.
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- 신산업융합대학 > 식품영양학과 > Journal papers
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