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Clinical significance of lactate clearance for the development of early allograft dysfunction and short-term prognosis in deceased donor liver transplantation

Title
Clinical significance of lactate clearance for the development of early allograft dysfunction and short-term prognosis in deceased donor liver transplantation
Authors
Kim D.G.Lee J.Y.Jung Y.B.Song S.H.Lee J.G.Han D.H.Joo D.J.Ju M.K.Choi G.H.Choi J.S.Kim M.S.Kim S.I.
Ewha Authors
송승환
Issue Date
2017
Journal Title
Clinical Transplantation
ISSN
0902-0063JCR Link
Citation
vol. 31, no. 12
Keywords
early allograft dysfunctionlactate clearanceliver transplantation
Publisher
Blackwell Publishing Ltd
Indexed
SCI; SCIE; SCOPUS WOS scopus
Abstract
This retrospective study evaluated lactate clearance (LC), measured at 6, 12, 18, and 24 hours after reperfusion, as a predictor of early allograft dysfunction (EAD) and short-term outcomes in patients receiving deceased donor liver transplantation. Of 181 transplant recipients, 44 (24.3%) developed EAD and had lower LCs than those who did not develop EAD. A receiver operating characteristic analysis showed that LC determined at 6 hours showed the highest area under curve value of 0.828 (95% confidence interval [CI]: 0.755-0.990) for predicting the development of EAD at a cutoff value of 25.8% with 76.7% sensitivity and 77.9% specificity. LC values that fell below the cutoff values were significantly associated with EAD in a multivariate analysis, with values at 6 hours having the highest adjusted odds ratio (11.891, 95% CI: 4.469-31.639). In-hospital and 6 month mortalities were higher in patients with LC values below the cutoffs compared with those above the cutoff values at each time point. Thus, LC calculated shortly after reperfusion of an allograft is significantly discriminative for the development of EAD and is associated with short-term prognosis after deceased donor liver transplantation. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DOI
10.1111/ctr.13136
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의료원 > 의료원 > Journal papers
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