Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오세관 | * |
dc.contributor.author | 정재철 | * |
dc.date.accessioned | 2018-01-11T16:30:21Z | - |
dc.date.available | 2018-01-11T16:30:21Z | - |
dc.date.issued | 2017 | * |
dc.identifier.issn | 1420-3049 | * |
dc.identifier.other | OAK-21740 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/239650 | - |
dc.description.abstract | Practical synthesis and biological activities of 4-hydroxy-3-methoxy-2-propene derivatives are described. The novel chalcone derivatives were prepared by acid catalysed one-step condensation of 1,3- or 1,4-diacetylbenzene and 1,3,5-triacetylbenzene with 4-hydroxy-3-methoxybenzaldehyde. They were then evaluated for free radical scavenging activity, suppression of lipopolysaccharides (LPS)-induced NO generation, and anti-excitotoxicity in vitro. It was found that all compounds showed good effects for 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, LPS-induced NO generation, and anti-neurotoxicity. Compounds 6 and 7 were potent suppressor of NO generation with the concentration range 10 mu M and especially compound 8 showed very potent anti-inflammatory activity with 1 mu M. In addition, the di- and tri-acetylbenzyl derivatives 6, 7, and 8 showed enhanced anti-neurotoxicity activity in cultured cortical neurons. Molecular modelling studies to investigate the chemical structural characteristics required for the enhanced biological activities interestingly revealed that compound 8 has the smallest highest occupied molecular orbital-lowest energy unoccupied molecular orbital (HOMO-LUMO) gap, which signifies easy electron and radical transfer between HOMO and LUMO in model studies. | * |
dc.language | English | * |
dc.publisher | MDPI AG | * |
dc.subject | chalcones | * |
dc.subject | condensation reaction | * |
dc.subject | free radical scavenging | * |
dc.subject | NO generation | * |
dc.subject | neurotoxicity | * |
dc.subject | molecular modelling | * |
dc.title | Practical Synthesis of Chalcone Derivatives and Their Biological Activities | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 22 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | MOLECULES | * |
dc.identifier.doi | 10.3390/molecules22111872 | * |
dc.identifier.wosid | WOS:000416528400073 | * |
dc.identifier.scopusid | 2-s2.0-85033774243 | * |
dc.author.google | Jung, Jae-Chul | * |
dc.author.google | Lee, Yongnam | * |
dc.author.google | Min, Dongguk | * |
dc.author.google | Jung, Mankil | * |
dc.author.google | Oh, Seikwan | * |
dc.contributor.scopusid | 오세관(7404103757) | * |
dc.contributor.scopusid | 정재철(7402897187) | * |
dc.date.modifydate | 20240123112233 | * |